经方小建中汤对老龄鼠胃衰老影响的实验研究  

Experimental Study on the Impact of the Experienced Formula Xiaojianzhong Decoction on Gastric Aging in Senile Rats

作　　者：陈光顺[1] 张朝宁[2] 余臣祖[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]甘肃中医学院附属医院,甘肃兰州730000

出　　处：《世界中西医结合杂志》2010年第9期755-757,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：甘肃省教育厅科研项目(No.044B-07)

摘　　要：目的观察小建中汤的抗胃衰老作用。方法 45只老龄Wistar大鼠随机分为空白组、模型组、小建中汤组,每组15只。除空白组外其余各组大鼠以10%D-半乳糖腹腔注射(剂量为140mg·kg-1.d-1)造成衰老模型;小建中汤组造模同时予小建中汤灌胃。8周后检测各组大鼠胃黏膜、肝组织SOD活性及MDA含量,摘取大鼠胸腺、脾和胃称重并计算脏器指数。结果给药后小建中汤组脾、胃和胸腺的脏器指数显著增加,与模型组比较,差异有统计学意义(P<0.01);小建中汤组胃黏膜、肝组织中SOD活性升高,MDA含量降低,与模型组比较,差异有统计学意义(P<0.05)。结论小建中汤具有抗氧化、清除自由基、修复胃黏膜损伤等作用,具有一定的延缓胃衰老作用。Objective To observe the action of xiaojianzhong decoction on anti-gastric aging.Methods 45 senile Wistar rats were divided randomly into blank group,model group and xiaojianzhong decoction group,15 rats in each one.Except blank group,the rats in the rest groups were prepared into aged model with the intraperitoneal injection of 10% D-galactose（140 mg·kg-1·d-1）.While modeling in xiaojianzhong decoction group,the gastric infusion with xiaojianzhong decoction was applied.8 weeks later,SOD activity and MDA content of gastric mucosa and liver tissue were detected in rats of each group.The rat thymus,spleen and stomach were removed and weighted,and the organ index was calculated.Results After medication,the organ index of spleen,stomach and thymus of rats in xiaojianzhong decoction group increased significantly,indicating statistical significant difference as compared with model group（P0.01）.In xiaojianzhong decoction group,SOD activity of gastric mucosa and liver tissue increased and MDA content decreased,indicating statistical significant difference as compared with model group（P0.05）.Conclusion Xiaojianzhong decoction acts on anti-oxidation,removal of free radicals,repair of gastric mucosal injury and others and has a certain effect on delaying gastric aging.

关 键 词：小建中汤 胃衰老 实验研究 

分 类 号：R289.5[医药卫生—方剂学]