电阻抗法细菌药物敏感快速检测装置的研制  

Rapid Detection Device of Bacteria Drug-sensitivity using Electrical Impedance Method

作　　者：王洪志[1,2] 庞小峰[1] 王爱华[2] 

机构地区：[1]电子科技大学生命科学与技术学院生物电磁学与生物电子技术四川省重点实验室,成都市610054 [2]西南民族大学生命科学与技术学院生理实验室,成都市610041

出　　处：《中国医疗器械杂志》2010年第5期326-329,共4页Chinese Journal of Medical Instrumentation

摘　　要：报告利用细菌在生长繁殖过程中的代谢产物可使培养基电阻率降低的特性,研制一种电阻抗法细菌药物敏感快速检测装置,该装置主要由微生物电阻抗传感器、计算机系统、信号发生器、电阻抗检测电路、时间程序分配控制器、恒温培养箱和辅助电路等组成。它可测量培养基电阻抗,并将细菌在培养期间内取得的阻抗值描记成阻抗曲线图,利用这种阻抗曲线的形态差别判断细菌的药物敏感性。该检测装置缩短了细菌药物敏感检测的时间,对实现医学临床快速药物敏感试验、药敏检测自动化和智能化有一定的实际意义。Since the bacteria metabolites in the process of growth and reproduction of can lower the resistivity characteristics of the medium,the electrical impedance method can develop a rapid detection device of bacterial drug sensitivity. The device consists of micro-organisms impedance sensors,computer systems,signal generator,resistance Anti-detection circuit,the time allocation controller,constant temperature incubator and auxiliary circuits and other components. It measures the electrical impedance of the medium,and bacteria in the culture period to obtain the impedance value of the monitor into the impedance curve. Drug sensitivity of bacteria can be determined,using this form of differential impedance curve. This detection device significantly shortened the time of bacterial drug susceptibility testing,achieving rapid drug susceptibility testing of clinical medicine,drug susceptibility testing automation and intelligence.

关 键 词：阻抗法 细菌药物敏感 阻抗曲线 检测装置 

分 类 号：R318.6[医药卫生—生物医学工程]