炎症因子与十二指肠溃疡寒热辨证的关系  

Relationship of Cytokines and Cold Heat Syndrome Differentiation in Patients of Duodenal Ulcer

作　　者：张学智[1,2] 纪宝安[1,2] 陈宝雯[1,2] 谢竹藩[1,2] 

机构地区：[1]北京医科大学第一医院中西医结合研究所 [2]北京医科大学第一医院消化科

出　　处：《中国中西医结合杂志》1999年第5期267-269,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金

摘　　要：目的：探讨炎症因子与十二指肠溃疡的寒热辨证关系。方法：对４８例十二指肠溃疡患者进行中医寒热辨证，胃镜下作胃窦部活检，测定胃粘膜组织白介素８（ＩＬ８）及白介素６（ＩＬ６），并测定肿瘤坏死因子（ＴＮＦ）、丙二醛（ＭＤＡ）、髓过氧化物酶（ＭＰＯ），然后进行对比分析，并与１０例正常胃粘膜活检标本作比较。结果：热证组胃粘膜ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ较寒证组增多（Ｐ＜００５）；ＩＬ６与寒热辨证无明显关系。结论：炎症因子ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ与中医寒热辨证有一定的相关性，可能是中医寒热证型形成的物质基础之一。Objective: To explore the relationship of cytokines and Cold Heat Syndrome in patients of duodenal ulcer. Methods: Cold Heat Syndrome Differentiation was done in 48 patients of duodenal ulcer, and the levels of interleukin 8 (IL 8), interleukin 6 (IL 6), tumor necrosis factor (TNF), malonyldialdehyde (MDA), marrow peroxidase (MPO) in gastric mucosa biopsy were measured and compared with those of 10 normal subjects. Results: Levels of IL 8, TNF, MPO and MDA in Heat Syndrome were higher than those in Cold Syndrome (P<0 05), while IL 6 level showed no significant relationship with Cold Heat Syndrome. Conclusion: Cytokines IL 8, TNF, MPO and MDA are correlated with Cold Heat Syndrome in duodenal ulcer patients and which might be one of the molecular mechanisms of Cold Heat Syndrome Differentiation.

关 键 词：炎症因子 十二指肠溃疡 中医寒热辨证 

分 类 号：R259.731[医药卫生—中西医结合]