卡介菌多糖核酸治疗变应性鼻炎疗效观察  

Efficacy of bacille calmette-guerin polysaccharide nucleic acid in the treatment of allergic rhinitis

作　　者：王培兰[1] 马秀清[1] 蔡兰萍[2] 陈良安[1] 刘又宁[1] 

机构地区：[1]解放军总医院呼吸科,北京100853 [2]解放军总医院医务室,北京100853

出　　处：《中国药物应用与监测》2010年第4期202-204,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨卡介菌多糖核酸治疗变应性鼻炎的疗效。方法:61例变应性鼻炎患者随机分为两组,试验组31例给予卡介菌多糖核酸注射液,每次0.70mg,隔日1次,肌内注射;对照组30例给予口服西替利嗪片,每次10mg,每晚1次。两组疗程均为3周,疗程结束后随访3年以确定其临床有效率。结果:治疗3d和1周时,试验组总有效率分别为77.42%和87.10%,对照组均为86.67%,两组差异无统计学意义(P>0.05)。停药后1年和3年随访显示,试验组总有效率分别为61.29%,48.39%,对照组分别为36.67%,26.67%,两组差异有统计学意义(P<0.05)。两组患者无严重不良反应发生。结论:卡介菌多糖核酸治疗变应性鼻炎临床疗效好、安全性高、症状复发率低。Objective： To evaluate the efficacy of bacille calmette-guerin polysaccharide nucleic acid （BCG-PSN） in the treatment of allergic rhinitis. Methods： Sixty-one patients with allergic rhinitis were divided into two groups. Thirty-one patients in the trial group were given BCG-PSN injection 0.70 mg every two days, and the other 30 patients in the control group were orally given 10 mg of cetirizine tablet every evening. All patients were treated for 3 weeks. The effective rates of two groups were evaluated after a 3-year follow-up period. Results： The total effective rates of the trial group were 77.42% and 87.10% for 3-day and 1-week treatment, and the effective rates of the control group were both 86.67%. There were no significant differences between two groups （P〉 0.05）. In the 1-year and 3-year follow-up after treatment, the total effective rates of the trial group were 61.29% and 48.39%, while those in the control group were 36.67% and 26.67%, respectively, there were significant differences between two groups （P〈 0.05）. No serious adverse event was observed in two groups. Conclusion： BCG-PSN against allergic rhinitis showed good efficacy, high safety, low relapse.

关 键 词：卡介菌多糖核酸 变应性鼻炎 疗效观察 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]