血小板活化因子拮抗剂WEB2170对烫伤大鼠肠粘膜微循环的影响  

The effects of platelet activating factor antagonist on intestinal mucosal microcirculation after scalding in rats

作　　者：余佩武[1] 肖光夏[2] 秦孝健[2] 周立新[2] 

机构地区：[1]第三军医大学附属西南医院普通外科 [2]第三军医大学附属西南医院烧伤研究所

出　　处：《第三军医大学学报》1999年第5期329-331,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：进一步探讨血小板活化因子（ＰＡＦ）在烧伤后肠粘膜屏障损害中的作用机制。方法：在大鼠３０％Ⅲ度烫伤模型上，观察ＰＡＦ拮抗剂ＷＥＢ２１７０对烧伤后肠粘膜血流量、肠粘膜内ｐＨ（ｐＨｉ）和肠组织含水量的影响。结果：烫伤后肠粘膜血流量和ｐＨｉ较对照组显著降低，而肠组织含水量显著增多。应用ＰＡＦ拮抗剂ＷＥＢ２１７０治疗能有效改善烫伤后肠粘膜血流量，提高肠粘膜ｐＨｉ，并有效降低肠组织含水量，从而明显减轻肠粘膜病理损害。结论：ＰＡＦ是导致烧伤后肠粘膜微循环障碍的重要因素之一。Objective: To investigate the effects and their mechanism of platelet activating factor (PAF) antagonist on the intestinal mucosal microcirculation after scalding in rats. Methods: The changes of intestinal mucosal blood flow, intestinal intramucosal pH (pHi) and intestinal water content were determined on rats suffering from 30% TBSA third degree scalding and treated with PAF antagonist WEB2170. Results: PAF antagonist treatment of the scalded rats could significantly increase intestinal mucosal blood flow and pHi, decrease intestinal water content and alleviate evidently the intestinal mucosal damages as compared with those of the control group. Conclusion: PAF is one of the important factors to result in postburn disturbance of intestinal mucosal microcirculation.

关 键 词：血小板活化因子 肠粘膜 烧伤 微循环 

分 类 号：R644[医药卫生—外科学] R364.1[医药卫生—临床医学]