大鼠海马CA1区长时程增强的发育变化  

Developmental changes of longterm potentiation in hippocampus CA1 region in rats*

作　　者：熊鹰[1] 蔡文琴[1] 李希成[1] 隋建峰[1] 

机构地区：[1]第三军医大学基础医学部生理学教研室

出　　处：《第三军医大学学报》1999年第5期332-334,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：探讨大鼠发育过程中海马ＣＡ１区ＬＴＰ的变化。方法：刺激海马ＣＡ３区Ｓｃｈａｆｆｅｒ侧枝，在ＣＡ１锥体细胞层记录ＬＴＰ。结果：１月龄大鼠海马ＣＡ１区ＬＴＰ诱出率最低，２、６月龄大鼠诱出率均高于１月龄大鼠；串刺激后，２月龄大鼠平均峰潜期显著缩短，而１、６月龄大鼠无明显变化；各年龄组大鼠ＰＳ峰值在串刺激后均明显增加，但１月龄大鼠ＰＳ增幅最小，２月龄大鼠ＰＳ增幅最大，ｆＥＰＳＰ斜率的变化与ＰＳ增幅的变化基本一致。结论：ＬＴＰ随发育进程有明显的变化，２月龄大鼠ＬＴＰ效应强于其他年龄组大鼠。Objective: To investigate the developmental changes of longterm potentiation (LTP) in the hippocampus CA1 region. Methods: Schaffer lateral branch in CA3 region was simulated to record LTP in CA1 region. Results: The probability of the induction of LTP in the CA1 region in 1monthold rats was the lowest among all groups. The PS amplitude and fEPSP slope of different age rats were significantly increased after tetanic stimulation but the intensity of LTP in 2monthold rats was stronger than those in 1monthold and 6monthold rats. Conclusion: There are obvious developmental changes of LTP and the intensity of LTP in 2monthold rats is the highest.

关 键 词：长时程增强 发育 海马 大鼠 

分 类 号：R339.35[医药卫生—人体生理学] R338.26[医药卫生—基础医学]