低压缺氧对哮喘豚鼠血浆皮质醇含量和血液淋巴细胞β受体的影响  

Effects of hypobaric hypoxia on plasma cortisol and lymphocytic receptor in asthmatic guinea pigs

作　　者：桂芹[1] 孔祥英[1] 白家驷[1] 

机构地区：[1]第三军医大学附属西南医院小儿科

出　　处：《第三军医大学学报》1999年第5期351-354,共4页Journal of Third Military Medical University

摘　　要：目的：探讨低压缺氧治疗哮喘的机制。方法：采用卵蛋白致敏和激发制成豚鼠哮喘模型，比较正常组、诱发哮喘发作后２４ｈ（发作组）、未经任何治疗哮喘豚鼠（对照组）以及低压缺氧治疗哮喘豚鼠（治疗组）的血浆皮质醇、外周血淋巴细胞β受体数目以及肺组织病理学变化。结果：①皮质醇水平：发作组较正常组显著升高（Ｐ＜０．０１），对照组较正常组明显下降（Ｐ＜０．０１），治疗组较对照组显著升高（Ｐ＜０．０１），与正常组差异不显著（Ｐ＞０．０５）。②外周血淋巴细胞β受体数：对照组较正常组明显减少（Ｐ＜０．０１），治疗组较对照组明显增加（Ｐ＜０．０５），与正常组差异显著（Ｐ＜０．０５）。③肺组织病理学变化：治疗组较对照组明显好转，ＥＯＳ浸润减少，肺泡膈间质水肿基本消失，Ⅱ型肺泡上皮增生。结论：低压缺氧治疗哮喘豚鼠后血浆皮质醇水平升高以及外周血淋巴细胞β受体数目增加，可能是低压缺氧治疗哮喘的机制。Objective: To explore the mechanism of the therapeutic effects of hypobaric hypoxia on asthmatic guinea pigs. Methods:ZAfter the model of asthma was established by ovalbumin (OA) challenge in OA sensitized guinea pigs,the animals was randomized into the asthmatic group (AG),the nontreated group (NTG) and hypobaric hypoxiatreated group (HHTG).The level of plasma cortisol and the lymphocytic receptor in peripheral blood were determined.The pulmonary pathological changes were observed with optical microscope and electron microscopy. Results: The level of plasma cortisol was significantly higher in AG than in normal control (NC) (P<0.01).But the level of plasma cortisol was significantly lower in NTG than in HHTG(P<0.01).The number of lymphocytic receptor was significantly increased in HHTG as compared with the NTG (P<0.05) and it was markedly lower in NTG than in NC (P<0.01).Infiltration of EOS in the alveolar septum,evacuation of lamellar body and interstitial edema of the alveolar septum were see while all these were improved in HHTG and the alveolar type cell proliferated. Conclusion: After the treatment with hypobaric hypoxia,the level of plasma cortisol and number of lymphocytic receptor in perpheral blood were significantly increased.All these may be the mechanism of the therapeutic effects of hypobaric hypoxia on asthma.\;

关 键 词：低压 缺氧 哮喘 皮质醇 Β受体 淋巴细胞 

分 类 号：R562.250.5[医药卫生—呼吸系统]