The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis  

作　　者：Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han 

机构地区：[1]Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an 710032, China [2]Department of Ophthalmology, Xifing Hospital, Fourth Military Medical University, Xi' an 710032, China [3]Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai 200092, China

出　　处：《Journal of Genetics and Genomics》2010年第9期573-582,共10页遗传学报（英文版）

基　　金：supported by the grants from the Natural Science Foundation of China (Nos.30770693 and 30830067);the Ministry of Science and Technology of China (No. 2009CB521706)

摘　　要：The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neo adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controUing tool that could have important applications in treatment of retinal diseases.The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neo adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controUing tool that could have important applications in treatment of retinal diseases.

关 键 词：Notch signaling retinal dysplasia vascular homeostasis NEOVASCULARIZATION knockout mice 

分 类 号：Q421[生物学—神经生物学] TP391.41[生物学—生理学]