初发高血压患者血压昼夜节律变化与动脉弹性的关系  

Relationship Between Day-night Rhythm and Arterial Elasticity in Patients with Initial Hypertension

作　　者：张雪姣[1] 熊子波[2] 林慧玲[1] 林中[1] 

机构地区：[1]深圳市福田区慢性病防治院慢非科,广东深圳518048 [2]北京大学深圳医院肾内科

出　　处：《实用预防医学》2010年第9期1723-1725,共3页Practical Preventive Medicine

基　　金：深圳市福田区科技局科研项目(FTWS070)

摘　　要：目的探讨初发高血压病患者血压昼夜节律变化与动脉弹性的关系。方法将186例初发原发性高血压病患者按照24 h动态血压检测结果分为A、B两组:A组为杓形组,共71例;B组为非杓形组,共115例,分别检测血清超敏C反应蛋白和动脉弹性水平。结果 B组的超敏C反应蛋白水平明显高于A组[(6.97±13.17)mg/L vs(2.34±1.49)mg/L,P<0.01],B组的踝肱脉搏波传导速度明显高于A组[(1 603.35±213.26)cm/s vs(1 340.10±265.76)cm/s,P<0.01],B组患者和A组踝臂指数(ABI)差异无统计学意义(1.21±0.24 vs 1.13±0.18)。结论初发高血压病患者血压昼夜节律变化与炎症反应、动脉弹性关系密切。Objective To explore the relationship between day-night rhythm and serum level of high sensitive C reactive protein（hs-CRP）,brachial-ankle pulse-wave velocity（baPWV）,ankle brachial index（ABI） in patients with initial hypertension. Methods According to the blood pressure-decreasing ratio,186 essential hypertensive patients were divided into dipping group（n=71） and non-dipping group（n=115）.ABI,baPWV and hs-CRP in these patients were examined at the same time. Results The level of hs-CRP in non-dipping group was significantly higher than that of dipping group [（6.97±13.17） mg/L vs（2.34±1.49） mg/L,P0.01].The baPWV in non-dipping group was significantly higher than that of dipping group [（1,603.35±213.26） cm/s vs（1,340.10±265.76） cm/s,P0.01].No statistically significant difference was found in ABI between the two groups（1.21±0.24 vs 1.13±0.18）. Conclusions Day-night rhythm in patients with initial hypertension is closely correlated with inflammation and arterial elasticity.

关 键 词：高血压 昼夜节律 超敏C反应蛋白 动脉弹性 

分 类 号：R544.1[医药卫生—心血管疾病]