微RNA在多聚谷氨酰胺病中的作用研究进展  

Research progress in roles of microRNA in polyglutamine diseases

作　　者：师玉亭[1] 江泓[1] 唐北沙[1] 

机构地区：[1]中南大学湘雅医院神经内科,中南大学神经退行性疾病研究中心 ,长沙410008

出　　处：《中华医学遗传学杂志》2010年第4期406-409,共4页Chinese Journal of Medical Genetics

基　　金：基金项目：国家自然科学基金资（30971585,30871354.30710303061,30400262）;湖南省自然科学基金重点项目（08JJ3048）

摘　　要：多聚谷氨酰胺（polyglutamine,PolyQ）病是一类因致病基因编码区的三核苷酸重复异常扩增而形成PolyQ肽链,最终导致选择性神经元变性乃至死亡的神经退行性疾病,其发病机制仍未完全阐明.微RNA（microRNA,miRNA）作为一种新的非蛋白质的基因表达调控因子,对真核生物的基因表达有非常重要的调控作用.近年来国内外学者日益关注miRNA在神经退行性疾病尤其是Po1yQ病中的功能及其作用机制.就目前miRNA在PolyQ病发病机制中的作用研究进展予以综述.Polyglutamine （Poly Q） diseases are a group of neurodegenerative disorders, caused by the formation of PolyQ mutants due to trinucleotide repeats expansion in coding regions of disease-causing genes, which eventually lead to selective neuronal degeneration and death with unclarified pathogenesis. As a new type of genetic regulatory factor, microRNA （miRNA） plays an important role in modulating gene expression in eukaryote. During the recent years, more attention was paid to roles and related mechanism of miRNA involving in neurodegenerative disease, especially PolyQ diseases. This review is focused on research progress in roles of miRNA in the pathogenesis of PolyQ diseases.

关 键 词：微RNA 多聚谷氨酰胺病 基因表达调控 靶基因 信使RNA 

分 类 号：R596[医药卫生—内科学]