再次直视心脏瓣膜置换术疗效分析  

Reoperative valve replacement in patients undergoing cardiac reoperation： a report of 104 cases

作　　者：邹良建[1] 徐志云[1] 王志农[1] 郎希龙[1] 韩林[1] 陆方林[1] 徐激斌[1] 唐昊[1] 纪广玉[1] 王尔松[1] 王军[1] 曲艺[1] 

机构地区：[1]第二军医大学长海医院胸心外科,上海200433

出　　处：《中华外科杂志》2010年第16期1214-1216,共3页Chinese Journal of Surgery

摘　　要：目的 总结再次直视心脏瓣膜置换术的治疗体会.方法 2002年1月至2009年12月完成再次直视心脏瓣膜置换术104例,占同期瓣膜置换手术的2.92%（104/3557）.男性53例,女性51例,年龄13～72岁,平均（46±14）岁.心功能（NYHA分级）Ⅱ级7例,Ⅲ级67例,Ⅳ级30例.其中二尖瓣或主动脉瓣置换术后其他瓣膜病变28例,二尖瓣瓣膜成形术后再发二尖瓣关闭不全10例,瓣周漏19例,生物瓣衰败7例,先天性心脏病矫治术再发瓣膜病变18例,人工瓣膜心内膜炎10例,人工瓣膜机械功能障碍9例,其他3例.再次手术方式包括二尖瓣和主动脉瓣双瓣置换2例,二尖瓣置换59例,主动脉瓣置换24例,三尖瓣置换16例,Bentall术3例.两次手术间隔1个月～19年.结果 全组早期死亡8例,早期死亡主要原因为术后低心排血量综合征、肾功能不全或多脏器功能衰竭,病死率7.7%.术中大出血2例,术后再次开胸止血2例,胸骨正中切口感染1例.随访3个月～7年2个月,平均3年4个月.晚期死亡2例,1例抗凝过量颅内出血,另1例原因不明.其余存活患者术后半年随访心功能（NYHA分级）Ⅰ级67例,Ⅱ级27例.结论 再次换瓣手术如恰当掌握手术时机、术中加强心肌保护、保证准确的手术操作、注重围手术期处理,临床近、远期效果满意.Objective To review the experience of reoperative valve replacement for 104 patients.Methods From January 2002 to December 2009, 104 patients underwent heart valve replacement in reoperations, accounting for 2.92% of the total patient population （3557 cases） who had valve replacement during this period In this group, 53 male and 51 female patients were included with a median age of 46 years （ ranged from 13 to 72 years ）. The reasons of reoperation included 28 cases sufered from another valve lesion after valve replacement, 10 cases suffered from valve lesion after mitral valvuloplasty, 19 cases suffered from perivalvular leakage after valve replacement, 18 cases suffered from valve lesion after previous correction of congenital heart defect, 7 cases sufered from bioprosthetic valve decline, 10 cases suffered from prosthetic valve endocarditis, 9 cases suffered from dysfunction of machine valve, and 3 cases suffered from other causes. The re-operations were mitral and aortic valve replacement in 2 cases, mitral valve replacement in 59 cases, aortic valve replacement in 24 cases, tricuspid valve replacement in 16 cases, and Bentall＇s operation in 3 cases. The interval from first operation to next operation was 1 month-19 years. Results There were 8 early deaths from heart failure, venal failure and multiple organ failure （early mortality 7.69%）. Major complications were intraoperative hemorrhage in 2 cases, re-exploration for mediastinal bleeding in 2 cases and stemotomy surgical site infection in 1 case. Complete follow-up （3 months-7 years and 2 months） was available for all patients. Two patients died, one patient died of intracranial hemorrhage,and another cause was unknown. Conclusion Satisfactory short-term and long-term results can be obtained in reoperative valve replacement with appropriate timing of operation control, satisfactory myocardial protection, accurate surgical procedure and suitable perioperative treatment.

关 键 词：心脏瓣膜假体植入 再手术 心内膜炎 细菌性 

分 类 号：R654.2[医药卫生—外科学]