血管内皮功能变化与慢性阻塞性肺疾病的关系  

Relationship between vascular endothelial function and chronic obstructive pulmonary disease

作　　者：郭瑛[1] 李燕芹[1] 刘斌[1] 徐佳波[1] 秦慧[1] 邹静[1] 

机构地区：[1]上海交通大学医学院附属仁济医院呼吸科,上海200127

出　　处：《上海交通大学学报（医学版）》2010年第9期1152-1155,共4页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血管内皮功能变化与COPD病情严重程度的相关性。方法选取2008年5月—2009年3月于仁济医院呼吸科就诊的COPD稳定期患者52例,分为轻度组(n=12)、中度组(n=12)、重度组(n=14)和极重度组(n=14);以26例健康志愿者作为对照组,分为健康吸烟对照组(n=13)和健康不吸烟对照组(n=13)。所有受试者接受肺功能检测,采用酶联免疫分析法(ELISA)和NO2-/NO3-硝酸还原酶法检测血浆内皮素-1(ET-1)、血管内皮生长因子(VEGF)和血清一氧化氮(NO)浓度。结果 COPD组血清NO和VEGF浓度均低于健康不吸烟对照组,差异有统计学意义(P<0.05);血清NO和VEGF浓度与第1秒用力呼气容积(FEV1)呈正相关(r=0.767,P<0.01;r=0.658,P<0.01)。COPD组血浆ET-1浓度均高于健康对照组,差异有统计学意义(P<0.05);血浆ET-1浓度与FEV1呈负相关(r=-0.816,P<0.01)。结论 COPD患者存在血管内皮功能紊乱,且与疾病的严重程度具有相关性。Objective To explore the relationship between vascular endothelial function and severity of chronic obstructive pulmonary disease （COPD）.Methods Fifty-two patients with COPD in stable phase visiting Department of Respiratory Medicine,Renji Hospital from May 2008 to March 2009 were selected,and were divided into mild group （n=12）,moderate group （n=12）,severe group （n=14） and extremely severe group （n=14）.Besides,another 26 healthy volunteers were served as control group,and were subdivided into healthy smoking control group （n=13） and healthy non-smoking control group （n=13）.Pulmonary function tests were performed in all subjects.Concentrations of plasma endothelin-1 （ET-1）,serum vascular endothelial growth factor （VEGF） and serum nitric oxide （NO） were detected by enzyme-linked immunosorbent assay （ELISA） and NO2-/NO3-nitrate reductase assay.Results The concentrations of serum NO and VEGF in COPD groups were significantly lower than those of healthy non-smoking control group （P0.05）.The concentrations of serum NO and VEGF were positively related to forced expiratory volume in one second （FEV1） （r=0.767,P0.01;r=0.658,P0.01）.The concentrations of plasma ET-1 in COPD groups were significantly higher than those in healthy control groups （P0.05）.The concentration of plasma ET-1 was negatively related to FEV1 （r=-0.816,P0.01）.Conclusion There exists vascular endothelial dysfunction in patients with COPD,which is closely related to disease severity.

关 键 词：慢性阻塞性肺疾病 血管内皮细胞 内皮素-1 一氧化氮 血管内皮生长因子 

分 类 号：R563.9[医药卫生—呼吸系统]