三种吸虫感染与胆管癌发病关系的研究进展  

Research Progress on the Relationship between Three Kinds of Liver Fluke Infections and Cholangiocarcinoma

作　　者：刘国兴[1] 吴秀萍[1] 王子见[1] 白雪[1] 刘明远[1] 

机构地区：[1]人兽共患病教育部重点实验室,吉林大学人兽共患病研究所,中国医学科学院病原生物学研究所人兽共患病研究中心

出　　处：《中国寄生虫学与寄生虫病杂志》2010年第4期301-305,共5页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：由华支睾吸虫(Clonorchis sinensis)、麝猫后睾吸虫(Opisthorchis viverrini)和猫后睾吸虫(Opisthorchis fe-lineus)所引起的吸虫病是严重危害人类健康的食源性寄生虫病,在亚洲地区流行较为广泛,人们通过食含有囊蚴的生鱼或虾类而感染。长期且重度感染会造成肝脏机能障碍,如胆结石和胆囊炎等。近年来,越来越多的研究表明这三种吸虫与胆管癌之间存在着病因学联系。本文对他们之间的关系及胆管癌可能的发病机制进行综述。Liver fluke disease caused by Clonorchis sinensis,Opisthorchis viverrini and O.felineus is a food-borne zoonotic parasitic disease and widely prevalent in Asia.The definitive hosts including human beings get the infection by ingestion of raw or undercooked fish or shrimp infested with metacercariae.Long-term or severe infection of the flukes can lead to dysfunction of the liver,such as cholelithiasis,cholecystitis,and so on.Researches indicated that there is an etiology relation between the fluke infection and cholangiocarcinoma.This paper reviews the relationship and possible mechanisms of the liver fluke-associated cholangiocarcinoma

关 键 词：华支睾吸虫 麝猫后睾吸虫 猫后睾吸虫 胆管癌 发病机制 

分 类 号：R383.2[医药卫生—医学寄生虫学]