Genetics of stroke  

作　　者：Jin-min GUO Ai-jun LIU Ding-feng SU 

机构地区：[1]Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

出　　处：《Acta Pharmacologica Sinica》2010年第9期1055-1064,共10页中国药理学报（英文版）

基　　金：This work was supported by grants from the National Basic Research Program of China （973 Program, No 2009CB521901） and the National Natural Science Foundation of China （No 30730106, 30901809）.

摘　　要：Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

关 键 词：GENETICS STROKE ischemic stroke hemorrhagic stroke 

分 类 号：S828[农业科学—畜牧学] Q3[农业科学—畜牧兽医]