Type I natural killer T cells： naturally born for fighting  

作　　者：Jin-quan TAN Wei XIAO Lan WANG Yu-ling HE 

机构地区：[1]Department of Immunology [2]Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan 430071, China

出　　处：《Acta Pharmacologica Sinica》2010年第9期1123-1132,共10页中国药理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China （30730054, 30572119, 30670937, 30971279, 30901363）, the Hi-tech Research and Development Program of China from Ministry of Science and Technology （2007AA02Z120）, the Ministry of Education （20060486008, 20090141120011）, Provincial Department of Science and Tech- nology of Hubei （2007ABC010）, Provincial Department of Health of Hubei （JX4B14）, Innovation Program of Wuhan Uni- versity for Young Scholars （WU3082007）, National Innovation Experiment Program for College Students （WU2007061）, China, and Chang Jiang Scholars Program from Ministry of Education, China and Li Ka Shing Foundation, Hong Kong, China （Chang Jiang Scholar TJ）.

摘　　要：Type I natural killer T cells （NKT cells）, a subset of CDld-restricted T cells with invariant Vαβ TCR, are characterized by prompt production of large amounts of Thl and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type I NKT cells may play a critical role in modulating the upcoming immune responses, such as anti-tumor response, protection against infection, and autoimmunity. As a bridge between innate and adaptive immunity, type I NKT cells differentiate and mature upon stimulations to achieve and maintain a homeostasis. Orchestrating with other arms of adaptive immunity, type I NKT cells show strong cytotoxic effects in response to various tumors in a direct and/or indirect manner（s）. This review will focus primarily on type I NKT cell development, homeostasis, and effector functions, especJally in anti-tumor immunity, and followed by their potentia applications in treatment of cancers.Type I natural killer T cells （NKT cells）, a subset of CDld-restricted T cells with invariant Vαβ TCR, are characterized by prompt production of large amounts of Thl and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type I NKT cells may play a critical role in modulating the upcoming immune responses, such as anti-tumor response, protection against infection, and autoimmunity. As a bridge between innate and adaptive immunity, type I NKT cells differentiate and mature upon stimulations to achieve and maintain a homeostasis. Orchestrating with other arms of adaptive immunity, type I NKT cells show strong cytotoxic effects in response to various tumors in a direct and/or indirect manner（s）. This review will focus primarily on type I NKT cell development, homeostasis, and effector functions, especJally in anti-tumor immunity, and followed by their potentia applications in treatment of cancers.

关 键 词：NKT cells tumor immunity cell development and homeostasis Th1/Th2 cytokines 

分 类 号：S852.5[农业科学—基础兽医学] X591[农业科学—兽医学]