外阴上皮内非瘤样变的发病高危因素及组织学特征分析  

Analysis of high risk factors and histologic characteristics of vulvar intraepithelial non-neoplastic lesion

作　　者：刁雯静[1] 郭奇桑[1] 隋龙[1] 

机构地区：[1]复旦大学附属妇产科医院宫颈科,上海200011

出　　处：《复旦学报（医学版）》2010年第5期548-551,共4页Fudan University Journal of Medical Sciences

基　　金：上海市重点学科项目(B117)

摘　　要：目的探讨外阴上皮内非瘤样变发病高危因素以及临床和组织病理学特点,以期对该病有进一步认识。方法回顾分析2008年1月至2009年6月因外阴瘙痒以及外阴色素减退在我院就诊患者的临床资料,根据其发病的相关因素以及外阴病理组织学诊断的结果,探讨外阴上皮内非瘤样变发病的高危因素及组织学特性。结果所有临床表现为外阴色素减退及瘙痒的患者共79例,经病理组织学诊断为外阴皮肤上皮内非瘤样变者31例,诊断为非特异性皮肤组织慢性炎者48例。两组发病年龄与病程差异无统计学意义,发病因素中精神压力和化学物质或射线暴露史在两组间差异存在统计学意义,54.8%的患者存在不同程度的精神压力,其余因素如饮食偏好、抽烟饮酒、家族史及自身免疫性疾病等在两组间差异均无统计学意义。结论非特异性皮肤组织慢性炎可能是外阴上皮内非瘤样变前期的主要病理组织学改变类型,而精神压力和化学物质或射线曝露史可能是外阴上皮内非瘤样变的诱发因素。Objective To investigate the high risk factors and histologic characteristics of vulvar intraepithelial non-neoplastic lesion. Methods Retrospective analysis of clinical data of patients charactered by pruritus vulvae and depigmentation during Feb.2008 and Jun.2009 in our hospital was made. Results Altogether 79 cases were included.Histologic diagnosis confirmed 31 vulvar intraepithelial non-neoplastic lesion cases and 48 chronic non-specific vulvar cutaneous inflammation.Statistics difference was found between vulvar intraepithelial non-neoplastic lesion group and chronic non-specific vulvar cutaneous inflammation group concerning mental pressure and chemical agents or ray exposure history.There were no statistics difference between these two groups with respect to other factors such as age,duration,food,drink and smoke,family history and autoimmune disease history. Conclusions We suggested that chronic non-specific vulvar cutaneous inflammation should be the main prepathologic state of vulvar intraepithelial non-neoplastic lesion,and mental pressure and chemical agents or ray exposure history might be the causative factors.

关 键 词：外阴上皮内非瘤样变 高危因素 病理组织学 

分 类 号：R711.72[医药卫生—妇产科学]