Correlation between synaptic protein expression and synaptic reorganization in the hippocampal CA3 region in a rat model of post-traumatic epilepsy  

作　　者：Gaolian Zhang Jianmin Huang Bang Zhao Haineng Huang Yuanyang Deng HuadongHuang Qirong He Jianping Liang 

机构地区：[1]Department of Neurosurgery, First Affiliated Hospital, Guangxi Traditional Chinese Medicine University, Nanning 530023, Guangxi Zhuang Autonomous Region, China [2]Department of Neurology, Hospital Affiliated to Youjiang Medical University for Nationafities, Baise 533000, Guangxi Zhuang Autonomous Region, China [3]Department of Neurosurgery, Hospital Affiliated to Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

出　　处：《Neural Regeneration Research》2010年第15期1156-1160,共5页中国神经再生研究（英文版）

基　　金：the General Program of Department of Education of Guangxi Zhuang Autonomous Region,No.Guijiaokeyan[2007]34

摘　　要：Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models. However, the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear. FeCI2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy. Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry. Epileptiform discharge induced by FeCI2 injection was determined in rat forebrain neurons, revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days. Synaptophysin expression was markedly reduced at 24 hours, but increased at 7 days. Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCI2-induced epilepsy models.Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models. However, the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear. FeCI2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy. Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry. Epileptiform discharge induced by FeCI2 injection was determined in rat forebrain neurons, revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days. Synaptophysin expression was markedly reduced at 24 hours, but increased at 7 days. Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCI2-induced epilepsy models.

关 键 词：post-traumatic epilepsy HIPPOCAMPUS FeCI2 FOREBRAIN postsynaptic density protein-95 SYNAPTOPHYSIN brain injury neural regeneration 

分 类 号：Q954.52[生物学—动物学] S858.966[农业科学—临床兽医学]