两种骨修复材料修复兔颅骨骨缺损:X射线评估效果  

Two kinds of bone materials for repairing rabbit calvarial bone defects:X-ray assessment

作　　者：阳懿[1] 赵承初[2] 马征[3] 赵峰[2] 陈红亮[2] 孙勇[2] 

机构地区：[1]泸州医学院,四川省泸州市646000 [2]解放军成都军区机关医院口腔科,四川省成都市610011 [3]泸州医学院附属医院口腔颌面外科,四川省泸州市646000

出　　处：《中国组织工程研究与临床康复》2010年第34期6283-6286,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:虽然生物源性和无机源性骨组织替代材料各自的引导新骨再生的能力都得到证实,但目前就生物源性与无机骨组织替代材料对于颌骨缺损病理改变的骨增量和成骨效果有无差异尚无定论。目的:对比观察无机源性与生物源性骨组织替代材料在骨缺损再生修复中引导骨组织再生的能力与特点及差异。方法:建立成年新西兰兔颅顶骨洞型骨缺损模型,前方和后方洞型骨缺损区分别采用无机源性与生物源性骨粉填充并用胶原生物膜覆盖,保留硬脑膜面与海奥胶原膜双层膜之间的血凝块。于术后12,16,24周通过X射线观察分析骨缺损区组织修复状况。结果与结论:术后12,16,24周生物源性骨粉组和无机源性骨粉组新生骨量随时间增加明显上升,且生物源性骨粉组新生骨量均明显多于无机源性骨粉组新生骨量(P≤0.05)。结果说明无机源性与生物源性骨粉均可起到引导新骨再生完全修复骨缺损的作用,但生物源性骨粉修复骨缺损效果优于无机源性骨粉。BACKGROUND：At present,the ability of guiding new bone regeneration of the bio-derived and inorganic-derived bone tissue substitutes is verified,but their increased bony quantity guided and the osteopoietic effects have not been assured yet.OBJECTIVE：To observe and contrast the ability,feature and difference of two bone substitute materials in guiding bone tissue regeneration during bone defect repairs.METHODS：The hole-like calvarium defect models were established in 18 adult New Zealand rabbits.The front and back defects of the models were filled separately with inorganic-derived and bio-derived bone meals,then covered with collagen membranes.The blood clot between the cerebral dura mater and collagen membrane ware required to be retained.The repairing condition in the cranium defect areas was observed and analyzed in 12,16 and 24 weeks postoperation by X-rays.RESULTS AND CONCLUSION：The regenerating bony quantity increased along with time going,the quantity in the bio-group is obviously more than that of the inorganic-group in 12,16 and 24 weeks postoperation（P ≤ 0.05）.Inorganic-derived and bio-derived bone meal can both guide bony tissue regeneration and completely recover the calvarium defects.However,the bio-derived bone meal is better than the inorganic-derived meal.

关 键 词：生物源性 无机源性 骨组织替代材料 骨缺损 引导骨组织再生 生物材料与组织工程 

分 类 号：R318[医药卫生—生物医学工程]