可降解多孔淀粉/聚乙烯醇复合膜的结构与性能  

Structure and properties of biodegradable,porous starch/polyvinyl alcohol composite membrane

作　　者：朱爱臣[1] 石锐 袁润英 陈大福 张立群[1] 

机构地区：[1]北京化工大学材料科学与工程学院先进弹性体研究中心,北京市100029 [2]北京市创伤骨科组织工程研究所,北京市100035

出　　处：《中国组织工程研究与临床康复》2010年第34期6328-6332,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：北京市自然基金资助项目"新型引导组织再生膜的制备及骨缺损修复的应用研究"(2102020);北京市卫生局;北京市中医管理局青年科学研究资助项目"新型引导组织再生膜的设计;制备及用于桡骨骨缺损修复探索"(2009-016)~~

摘　　要：背景:针对现有材料存在的问题,课题组制备了淀粉/聚乙烯醇膜,研究其性能是否满足引导组织再生膜的要求。前期实验已经探讨制备工艺条件对膜性能的影响。目的:观察在最佳的制备工艺条件下淀粉/聚乙烯醇膜的断面结构、生物相容性和体外降解等相关性能。方法:采用溶液浇注,冷冻干燥的方法制备了可降解的多孔淀粉/聚乙烯醇膜。对在预冻温度为-30℃,溶液浓度为5%,聚乙烯醇和淀粉质量比分别为4:1和1:1时制备的淀粉/聚乙烯醇膜的性能进行表征。结果与结论:在淀粉/聚乙烯醇膜的内部都形成了相互关联的孔结构,质量比为1:1的淀粉/聚乙烯醇膜的孔径大于质量比为4:1淀粉/聚乙烯醇膜,L929细胞和MC3T3细胞都能在材料表面黏附生长,并且由于两种膜的降解速率不同,可以根据不同组织的修复速率调节淀粉/聚乙烯醇膜的降解速率,以满足组织的修复需要。BACKGROUND：The starch/polyvinyl alcohol（PVA） membrane was prepared to verify whether its property can meet the requirements of guided tissue regeneration membrane.Previous experiments have investigated the influence of preparation techniques on membrane performance.OBJECTIVE：To observe the cross-section structure,biocompatibility and in vitro degradation of the starch/PVA membrane at the optimal preparation conditions.METHODS：Biodegradable and porous starch/PVA membrane was prepared by solution casting and freeze-dried.At pre-freezing temperature-30 ℃ and the solution concentration 5%,PVA and starch mass ratio of 4：1 and 1：1,respectively,the prepared starch/PVA membrane was determined.RESULTS AND CONCLUSION：The interconnected porous structure was formed in the starch/PVA membrane,the pore size of starch/PVA membrane at 1：1 ratio was greater than that at 4：1.Both L929 cells and MC3T3 cells could grow in the membrane surface.The degradation rate of starch/PVA membrane can be regulated by the repairing rate of different tissues to meet the repair requirement.

关 键 词：淀粉 聚乙烯醇 多孔结构 生物相容性 可降解 

分 类 号：R318[医药卫生—生物医学工程]