心血管覆膜支架材料学特征与主动脉夹层病变的治疗  

Material characteristics of cardiovascular stent-graft and its treatment for aortic dissection

作　　者：李乐雯 张艳[1] 王家昆[1] 

机构地区：[1]海南省干部疗养院,海南省海口市571100

出　　处：《中国组织工程研究与临床康复》2010年第34期6401-6404,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:探讨心血管覆膜支架的材料学特征及其置入治疗主动脉夹层的临床应用。方法:应用万方数据库和中国期刊全文数据库(CNKI),由第一作者以"主动脉夹层;覆膜支架;生物材料;临床研究;并发症"等为检索词,检索1998/2010时限内与覆膜支架置入治疗主动脉夹层相关的文献。排除重复研究或较陈旧文献。结果:依据纳入排除标准共纳入18篇相关文献。覆膜支架是金属或合金血管内支架与人工(天然)的膜性结构相结合的产物,常用覆膜有涤纶和生物膜2类。涤纶取材方便,价格低廉,但缺乏弹性,不能扩张,有一定的致血栓源性;生物膜具有良好的生物相容性,并能促进内皮生长,是目前最有发展潜力的一种膜。从临床应用效果来看,覆膜支架治疗主动脉夹层的近期效果良好。结论:覆膜支架血管内置入近期内可有效治疗StanfordB型/DebakeyⅢ型主动脉夹层,是一种安全、有效的微创疗法,但远期疗效尚需长期、严密的随访研究证实。OBJECTIVE：To investigate the material characteristics of the cardiovascular stent-graft and the clinical application of stent placement for the treatment of aortic dissection.METHODS：Wanfang Database and China Academic Journal Full-text Database were retrieved on computer by the first author using the key words of ＂aortic dissection;stent-graft;biological materials;clinical research;complications＂ in Chinese between 1998 and 2010 for articles related to stent-graft treatment for aortic dissection.The repeated study or old literatures were excluded.RESULTS：According to inclusion and exclusion criteria,18 literatures were included.Stent-graft is a product of metal or alloy stent endovascular stent with artificial（natural） membrane structure,which is often coated with polyester and biofilm.Polyester is easily obtained,low-cost,but lacks flexibility and can not expand,may induce thrombosis;biofilm has good biocompatibility,and can promote endothelial growth,is the most potential membrane.As for the clinical application curative effect,stent-graft treatment of aortic dissection achieves good results. CONCLUSION：The endovascular stent-graft can effectively treat Stanford B type/Debakey III type aortic dissection,it is a safe and effective minimally invasive therapy,but long-term effects still need long-term and close follow-up study to be confirmed.

关 键 词：主动脉夹层 覆膜支架 生物材料 临床研究 并发症 

分 类 号：R318[医药卫生—生物医学工程]