骨关节炎动物模型:人工诱导与动物自发  

Animal model of osteoarthritis:Artificial induction versus spontaneous induction

作　　者：胡波[1] 胡志俊[1] 张有为[2] 王世伟[3] 

机构地区：[1]上海中医药大学脊柱病研究所,上海市20003 [2]上海中医药大学附属龙华医院骨伤科,上海市200032 [3]上海中医药大学附属龙华医院康复科,上海市200032

出　　处：《中国组织工程研究与临床康复》2010年第33期6202-6205,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：上海市科委基础研究重点课题(08JC1418700)~~

摘　　要：背景:骨性关节炎是一种随年龄增长而发生率明显增加的退行性关节疾病,随着社会人口的老龄化,该病发病率呈显著上升趋势,但其发病机制尚不清楚,临床也缺乏根治措施,需要相应的动物模型来进行研究。目的:探讨骨关节炎动物模型的制作、特点及应用情况。方法:计算机检索PubMed 2004-01/2009-10和中国期刊全文数据库2002-01/2009-10与骨关节炎动物模型相关的文献,分析各种骨关节炎模型的研究进展。结果与结论:共纳入骨关节炎动物模型制作相关文献34篇。人工诱发与动物自发均可获得成功的骨关节炎动物模型。通过手术方法人工诱发动物骨关节炎模型可能会引起关节其他损伤,进而对实验产生影响。而非手术方法诱发动物模型主要用于软骨病变及药物研究。动物自发模型适合骨关节炎的病理机制及防治骨关节炎的研究。在实验时应根据具体研究发祥选择动物模型。BACKGROUND：Osteoarthritis（OA） is a retrogressive arthrosis,incidence rate of which increased obviously with the age.Accompanying with the aging of the population,the incidence of this disease appears an upward trend significantly.The etiology and pathogenesis of OA is poorly understood,without cure measures.Thus,corresponding animal models are needed.OBJECTIVE：To explore preparation,characteristics and application of OA animal models.METHODS：A computer-based online search of PubMed databases was undertaken to identify the articles about the OA animal models published between January 2004 and October 2009.Meanwhile,Chinese Journal Full-text Database was searched for related Chinese articles published from January 2002 to October 2009.The researches concerning OA were analyzed.RESULTS AND CONCLUSION：Totally 34 documents addressing the preparation of OA were included in this paper.The OA models could be attained both by artificially and spontaneous induction.The study found that the artificial induced model by surgical method may result in damage to joints,further more,affects experimental results.Non surgical method in inducing OA models mainly used for the research of cartilaginous lesions and drugs.OA models prepared by spontaneous induction are more suitable for the pathological mechanisms and prevention methods of OA.Accordingly,the model preparation is depended on experimental focus.

关 键 词：骨关节炎 动物模型 综述文献 手术 自发 软骨组织工程 

分 类 号：R318[医药卫生—生物医学工程]