南昌地区汉族绝经前女性雌激素受体α基因PvuII遗传多态性与体质量指数的关系(英文)  

Correlating estrogen receptor-alpha PvuII genetic polymorphism with bone mass index in premenopausal Han Chinese women from Nanchang region

作　　者：徐宏[1] 彭婧[1] 张莉[1] 邹琳[2] 况海斌[1] 

机构地区：[1]南昌大学医学院生理学教研室,江西省南昌市330006 [2]江西省人民医院放射免疫室,江西省南昌市330006

出　　处：《中国组织工程研究与临床康复》2010年第33期6267-6270,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：the National Natural Science Foundation of China,No.30760071,30960118;A Grant from Education Department of Jiangxi Province,No.GJJ08106;Scientific Research Foundation of Nanchang University,No.J06~~

摘　　要：背景:肥胖是由多基因决定的复杂性疾病,体质量指数是研究肥胖的常用表型。有研究显示一些候选基因与体质量指数变异相关,然而它们之间的相互关系却仍未阐明。目的:探讨雌激素受体α基因(ER-α)PvuII多态性是否与体质量指数的变异相关联。方法:征集了绝经前女性390例,均来自南昌地区江西省人民医院的体检人员,测量其身高和体质量,计算体质量指数。用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法对所有被试者的雌激素受体α基因PvuII位点进行基因分型。结果与结论:雌激素受体α基因PP,Pp和pp基因型频率分别为0.133,0.485和0.382。雌激素受体α基因型分布符合哈迪-温伯格平衡(P>0.05)。雌激素受体α基因PvuII与体质量指数没有显著的关联性(P=0.338)。证实雌激素受体α基因PvuII多态性对南昌地区绝经前妇女体质量指数没有重要的影响。BACKGROUND： Obesity is serious complex disease determined by multiple genetic factors. Body mass index （BMI） is a common phenotype for obesity. Although some candidate genes have been shown to be related with BMI variation, the underlying substantial relationship remains poorly understood. OBJECTIVE： To investigate whether estrogen receptor-α（ER-α） Pvull genetic polymorphism is associated with BMI variation. METHODS： In total 390 premenopausal women from a local population of Nanchang City in Jiangxi Province People＇s Hospital. Body weight and height were measured. All participants were genotyped at the ER-α Pvull locus using polymerase chain reaction-restriction fragment length polymorphism. RESULTS AND CONCLUSION： The ER-α Pvull genotype frequencies of PP, Pp and pp were 0.133, 0.485 and 0.382, respectively. The distribution of ER-Pvull genotypes was in accordance with Hardy-Weinberg equilibrium （HWE） （P 〉 0.05）. There was no significant correlation between ER-α Pvull genetic polymorphism and BMI variation （P = 0.338）. These findings indicate that ER-α Pvull genetic polymorphism does not greatly affect BMI variation of premenopausal women in Nanchang region.

关 键 词：绝经前女性 体质量指数 雌激素受体基因 遗传关联 遗传多态性 

分 类 号：R589.2[医药卫生—内分泌]