无创人体血糖检测光学方法的研究现状与发展  

The Research Status and Development of Noninvasive Glucose Optical Measurements

作　　者：李刚[1] 周梅[1] 吴红杰[1] 林凌[1] 

机构地区：[1]天津大学,精密测试技术及仪器国家重点实验室,天津300072

出　　处：《光谱学与光谱分析》2010年第10期2744-2747,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(60674111)资助

摘　　要：糖尿病威胁着人类健康,血糖有创检测的弊端使无创检测方法成为糖尿病患者的迫切需求,无创血糖检测也因此成为国内外学术界研究的热点。但到目前为止还没有一种无创检测仪器有足够的精度能够应用于临床。文章中介绍了研究较多的光声光谱法、拉曼光谱法、荧光法、偏振光旋光法、光学相干层析成像法,近红外光谱法等光学光谱检测方法的原理、方法、特点以及当前国内外研究现状和进展。从中分析了限制血糖浓度无创检测应用于临床的技术难点问题及未来的研究方向,指出动态光谱方法是无创血糖测量中最有应用前景方法之一。Diabetes threatens the health of human beings.Because of the disadvantages of invasive glucose detection,Noninvasive glucose measurement which diabetics press for becomes the hotspot in both domestic and overseas academic circles.But up to now none of the available devices offers enough precision to clinical application.The principle,method,characteristics of optical spectrum measurements and current development at home and abroad are reviewed in the present paper,such as photoacoustic spectroscopy method,Raman spectrometry,fluorescence method,polarimetry,optical coherence tomography and near infrared spectroscopy.Then the problems and technical analysis of noninvasive glucose measurements as well as the development direction are discussed,and the dynamic spectrum is pointed out to be one of the most application prospect methods for noninvasive glucose measurement.

关 键 词：无创检测 糖尿病 血糖浓度 光谱检测 动态光谱 

分 类 号：O657.3[理学—分析化学]