腹膜间皮细胞EMT在腹膜纤维化中的研究进展及意义  

Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Peritoneal Fibrosis:Progression and Significance

作　　者：葛燕[1,2] 孙林[1,2] 刘伏友[1,2] 

机构地区：[1]中南大学湘雅二医院肾内科 [2]中南大学肾脏病研究所湖南省肾脏疾病与血液净化重点实验室,湖南长沙410011

出　　处：《医学与哲学（B）》2010年第9期46-47,54,共3页Medicine & Philosophy(B)

摘　　要：腹膜透析是终末期肾衰患者肾脏替代治疗的重要手段,腹膜纤维化导致腹透效能下降及超滤衰竭,制约着腹膜透析的应用。腹膜间皮细胞上皮细胞间充质转化是腹膜纤维化的起始和可逆环节,因此预防和逆转EMT的发生发展可能是阻止和延缓腹膜纤维化、超滤衰竭的最佳策略,并将带来巨大的社会和经济效益。Peritoneal dialysis （PD） is a very important therapy for patients with end stage renal disease. Peritoneal fibrosis is the main reason leading to declining efficiency and ultrafiltration failure of peritoneum, which restricts the application of PD. It is believed that the Epithelial - Mesenchymal Transition （EMT） of peritoneal mesothelial cells is reversible and the beginning step of peritoneal fibrosis, therefore, it may be the best strategy to prevent and delay the development of peritoneal fibrosis by interfering with EMT at the early stage, and it will definitely bring enormous social and economic benefits to the whole world.

关 键 词：上皮细胞-间充质转化(EMT) 腹膜间皮细胞 腹膜纤维化 转化生长因子-1(TGF-β1) 小分子RNA(miRNA) 

分 类 号：R692.5[医药卫生—泌尿科学]