高分子量聚乳酸用于SLS快速成型的研究  

Studies on the selective laser sintering of high molecular weight poly(D,L-lactic acid)

作　　者：傅亚[1,2] 程超[1,3] 张兵兵[1] 胡承波[1] 付春华[1] 王远亮[1] 

机构地区：[1]重庆大学生物工程学院、生物材料与仿生工程研究中心,重庆400030 [2]重庆科技学院生物系,重庆401331 [3]南阳理工学院,河南南阳473004

出　　处：《功能材料》2010年第9期1667-1670,共4页Journal of Functional Materials

基　　金：重庆市自然科学基金资助项目(2009BB4382);重庆市教育委员会科学技术研究资助项目(KJ091415);九龙坡区科技计划资助项目(高090109)

摘　　要：通过选区激光烧结技术(selective laser sintering,SLS),对高分子量聚(D,L-乳酸)(PDLLA)快速成型加工,研究该技术制造PDLLA组织工程支架的可行性。重均分子量80000,最大粒径120μm的PDLLA粉末,采用SLS技术快速成型,优化得到最佳控制参数,即预热温度为40℃、激光功率为12W、扫描速度1200mm/s。按照该参数加工测试件及人耳状支架,通过GPC-十八角激光光散射联用技术分析材料分子量的变化,力学测试仪分析成型材料的力学性能,扫描电镜分析支架材料的微观结构。结果显示高分子量的PDLLA可用于SLS加工成型,加工过程中高温会引起分子量部分降低,这种变化主要是激光接触面分子量降低所致,烧结作用不会改变材料的主要化学基团,力学测试显示烧结成型的材料能保留加工前聚合物20%的压缩模量,扫描电镜观察成型材料具有多孔结构,显示PDLLA用于SLS加工组织工程支架的潜能。This research focus on the use of a biocompatibility material,poly（D,L-lactic acid）（PDLLA）,to fabricate tissue engineering scaffolds using selective laser sintering （SLS） rapid prototyping（RP）.This particular form of PDLLA has a high molecular weight of 80000,a melting point of 100℃,and the largest particle size of 120μm.Effects of process parameter on the forming qualities were investigated.The parameters of the SLS process are optimized to cater to the process of manufacturing test specimens and human ear like scaffold.Optimal sintering conditions for the powders were achieved by varying parameters such as the part bed temperature,laser power,and scanning speed.GPC-multi-angle laser light scattering equipment and FTIR analysis was used to check the molecular weight and the chemical composition of PDLLA before and after sintering.Compression tests were performed using an Instron to analyze the mechanical properties.The mechanical properties were evaluated by using compression tests.The microstructure was characterized by using the scanning electron microscopy.This analysis confirmed that the molecular weight was reduced partly and its distribution was broadened.FTIR indicated that the chemical component of the sintered specimen was not changed.Mechanical testing showed that the sintered specimen reserved 20% modulus of compression of the specimen before sintering.SEM micrograph showed that the sintered PDLLA artificial ear with porous structure.The successful sintering of the test specimens shows the potential of producing PDLLA scaffolds on the SLS.

关 键 词：聚乳酸 快速成型制造 选区激光烧结技术 仿生制造 

分 类 号：TQ317[化学工程—高聚物工业]