复方菊花冲剂保留灌肠治疗溃疡性结肠炎的临床和实验研究  

The Clinical and Experimental Study on the Therapy of Retention Enema with Powder Preparation of Chrysanthemum Flower Compound in the Treatment of Ulcerative Colitis

作　　者：梅笑玲[1] 牛新玲 张忠春[1] 吴凯[1] 高善语[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011 [2]山东省章丘市中医院,山东章丘250200

出　　处：《中国肛肠病杂志》2010年第9期33-35,共3页Chinese Journal of Coloproctology

摘　　要：为探讨复方菊花冲剂保留灌肠治疗湿热内蕴型溃疡性结肠炎（UC）的临床疗效及作用机理，随机设复方菊花冲剂治疗组（30例）和柳氮磺吡啶对照组（30例），对治疗前后主要症状、体征积分值及肠镜黏膜像等进行对比观察，并造模形成大鼠UC，用药后观察大鼠结肠大体形态及结肠组织的病理变化。结果显示，治疗组在临床总疗效、主要症状、体征、黏膜像等方面均显著优于对照组（P〈0．05）。实验研究证明，复方菊花冲剂能促进大鼠肠黏膜炎症的吸收，促进溃疡修复愈合。结果表明，复方菊花冲剂保留灌肠治疗湿热内蕴型UC疗效确切，无明显副作用，使用方便。The objective of the study was to observe the clinical therapeutic efficacy and mechanism of the powder preparation of chrysanthemum flower compound（PPCFC） in the retention enema treatment of ulcerative colitis of damp-heat retention type（DHUC）. Sixty patients with DHUC were randomized into two groups,patients in the study group received PPCFC（ n = 30）,while patients in the control group received salicylazosulfapyridine （SASP）（ n =30）. Pre-and-post of treatment symptoms, sign score and enteroscopical mucosa image were observed and analyzed. Rat UC models were also made to observe the pathological change of the colon. Results showed that the general therapeutic efficacy, main symptoms, sign and colonic mucosa image were better in the study group than that in the control group（ P 〈0.05）. The experimental study also showed that PPCFC could promote the recovery of the colonic mucous inflammation and the healing of UC. It is concluded that PPCFC can ensure better therapeutic efficacy and convenience manipulation in retention enema treatment of UC of DHUC without notable side effect.

关 键 词：溃疡性结肠炎 复方菊花冲剂 保留灌肠 临床观察 实验研究 

分 类 号：R259.746.2[医药卫生—中西医结合]