糖基化终产物对人脐静脉内皮细胞产生一氧化氮量及其合酶的影响  

Effects of advanced glycosylation end-products on NO production and nitric oxide synthase activity in cultured human umbilical vein endothelial cells

作　　者：严金川[1] 黄晓明[1] 刘乃丰[1] 

机构地区：[1]南京铁道医学院心血管病研究室 [2]镇江市第四人民医院心内科

出　　处：《中国病理生理杂志》1999年第7期660-662,共3页Chinese Journal of Pathophysiology

摘　　要：目的和方法：利用体外培养的人脐静脉内皮细胞，观察糖基化终产物对该细胞产生一氧化氮（ＮＯ）及其对一氧化氮合酶（ＮＯＳ）活性的影响。结果：发现糖基化终产物组一氧化氮含量明显降低而一氧化氮合酶活性却明显增高，并随浓度、作用时间而发生相应变化。结论：糖基化终产物对内皮细胞产生一氧化氮的影响并不是通过降低ＮＯ合酶活性而起作用。AIM and METHODS: The effects of advanced glycosylation end-products (AGEs) on nitric oxide (NO) production and nitric oxide synthase (NOS) activity in cultured human umbilical vein endothelial cells (EC) were studied. RESULTS:AGEs decreased NO levels, however, significantly increased NOS activity in a dose and time dependent manner.CONCLUSION:Inhibition of NO production of AGEs be not contributed to the decrease of NOS activity.

关 键 词：糖基化终产物 内皮细胞 一氧化氮 糖尿病 NOS 

分 类 号：R587.102[医药卫生—内分泌]