聚原酸酯抗癌药物毫微囊的制备及体外释药研究  

PREPARATION AND DRUG RELEASE BEHAVIOR STUDY OF POLY (ORTHO ESTERS) ANTICANCER DRUG LOADED NANOCAPSULES

作　　者：常津[1] 魏民[1] 姚康德[1] 

机构地区：[1]天津大学高分子材料科学与工程研究所

出　　处：《中国生物医学工程学报》1999年第2期216-221,共6页Chinese Journal of Biomedical Engineering

摘　　要：采用Ｗ／Ｏ／Ｗ型复乳制备聚原酸酯载甲氨喋呤（ＭＴＸ）毫微囊微球，通过多种条件实验，制备了聚原酸酯载药毫微囊，并对药物体外释放动力学进行研究。结果表明有机溶剂组成、内部水相药物浓度、溶剂挥发温度等均对毫微囊的结构与性能产生影响，经优化所制备毫微囊粒径在５００～８００ｎｍ之间，药物包封率高。Anticancer drug loaded poly (ortho esters) nanocapsules were prepared using a doubleemulsification/solvent evaporation technique. The release characters and the affect factors were studied. The POE nanocapsules were regular in morphology with a mean diameter of 500800nm. The drug loaded ratio was about 30%. By using certain mixture solvent, drug concentration and lower evaporation temperature, the satisfactory nanocapsules can be obtained.

关 键 词：聚原酸酯 载药毫微囊 抗癌药 体外释药 

分 类 号：R979.1[医药卫生—药品] R318.08[医药卫生—药学]