莽草酸对动脉粥样硬化大鼠血脂及血液流变学影响的实验研究  

Experimental Studies on the Effect of Shikimic Acid on the Blood Lipid and Hemorrheology in Atherosclerosis Rats

作　　者：郑楚[1] 杨冬业[1] 徐勤[1] 韦桂宁[2] 

机构地区：[1]桂林医学院,广西桂林541001 [2]广西中医药研究院

出　　处：《中国药师》2010年第10期1394-1396,共3页China Pharmacist

基　　金：广西自然科学基金项目(编号:2010GXNSFA013255)

摘　　要：目的:探讨莽草酸对动脉粥样硬化(AS)大鼠血脂、血液流变学的影响。方法:采用高脂饲料复制动脉粥样硬化模型,观察莽草酸对动脉粥样硬化大鼠血脂、血液流变学指标的影响。结果:莽草酸可显著降低动脉粥样硬化大鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)水平,升高高密度脂蛋白(HDL)水平(P<0.05),并能显著降低动脉粥样硬化大鼠全血黏度(高、中、低切)、血浆黏度和红细胞压积(P<0.05)。结论:莽草酸可改善AS大鼠血脂水平和血液流变学指标,对AS具有一定的防治作用。Objective： To observe the effect of shikimic acid on blood lipid and hemorheology in atherosclerosis （AS） rats. Method： The AS model of rat was made by freeing high grease food, and the level of serum lipid and blood theology were tested. Result： Shikimic acid could obviously decrease TG, TC, LDL, hemotocrit, and blood viscosity, and increase HDL of atherosclerasis rats. Conclusion： Shikimic acid can adjust blood lipid and improve hemorrheo logy of atherosclerosis rats, and has therapentic effect for athemsclerosls.

关 键 词：莽草酸 动脉粥样硬化 血脂 血液流变学 大鼠 

分 类 号：R285.5[医药卫生—中药学]