磁共振频谱检测GABA的模拟和临床模型研究  

A method of detecting GABA by MRS simulation experimental and clinical model

作　　者：林月娟[1] 沈智威[2] 肖叶玉[2] 邱庆春[2] 吴仁华[2] 陈耀文[1] 

机构地区：[1]汕头大学中心实验室,汕头515063 [2]汕头大学医学院,汕头515041

出　　处：《中国体视学与图像分析》2010年第2期207-212,共6页Chinese Journal of Stereology and Image Analysis

基　　金：国家自然科学基金项目(60971075);汕头市科技计划项目(2008-64);汕头大学科研启动基金项目(2010)

摘　　要：目的通过研究检测GABA的模拟和临床模型,探讨建立一种稳定可靠的能够在体检测出GABA的方法。方法本研究利用双量子滤波技术,设计GABA谱编辑序列,基于乘积算符理论和相干路径选择理论讨论谱编辑的方法 ,并讨论提高检测效率的方案,优化谱编辑序列,并结合软件模拟结果讨论检测GABA的方案。结果使用NMR-SCOPE的模拟实验中,优化的DQF-PRESS序列能显著压制3.0ppm处的Cr,同时增强非常弱的GABA信号。结论本研究提供了一种有效的活体检测GABA的方法 ,而且描述了脉冲序列作用机制的数学及序列设计的理论,为后续研究者理解脉冲序列开发脉冲序列提供帮助。Objective To create a method of measuring GABA in vivo with spectral editing of MRS data. Methods DQF technology was used in the design and optimization of pulse sequence for GABA measurement. Product operator and coherence selection theory were adopted to discuss the pulse sequence design process, and its mathematical formula was described. In the simulation experiment using NMR-SCOPE, it was obvious that the Cr signal at 3.0 ppm was suppressed and the very low GABA signal was enhanced clearly with the optimized DQF-PRESS pulse sequence. The feasibility of the GABA detection method using LC Model was proved by a phantom experiment with clinic PRESS sequence. Results Proved that LC model was also an effective post-processing approach to separate GABA form the background of Cr. Conclusion To offer a new method for detecting GABA in vivo, and the mathematical formula of pulse sequence and theory of pulse design will help subsequent researchers to understand and design pulse sequence.

关 键 词：磁共振频谱(MRS) γ-氨基丁酸(GABA) 谱编辑 脑代谢物 

分 类 号：R445.2[医药卫生—影像医学与核医学]