抗生素筛选方法  

Methods for the screening of antibiotics

作　　者：马寅姣[1] 宋沁馨[2] 顾觉奋[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009 [2]中国药科大学药学院,南京210009

出　　处：《中国抗生素杂志》2010年第9期654-658,共5页Chinese Journal of Antibiotics

基　　金：江苏省基础研究计划(自然科学基金No.BK2008067);中央高校基本科研业务费专项资金青年项目(No.JKQ2009027)

摘　　要：细菌耐药性发生率的升高,激励着人们去寻找更多的筛选抗生素的策略,进而发现了更多的抗生素作用机制。靶向策略、高通量筛选等方法已经被用于检测有潜力的抗生素。细菌的DNA复制、细胞分裂和蛋白合成的中间步骤已经成为了筛选的新靶点,双组分信号传递系统也成为了较为重要的药物新筛选靶点。微生物基因组学的发展,给新抗生素的发现带来了更大的希望,使人们可以发现更多的新作用靶点。The increasing incidence of bacterial drug-resistance has stimulated the development of strategies for screening new antibiotics methods and thus revealed many unexploited mechanisms about the action of antibiotic. Target-directed strategies, high-throughput screens and other methods were being used to detect potential antibacterial agents. Bacterial DNA replication, cell division and synthesis of protein were the targets of new screening methods; two-component signaling systems were also being targeted. The development of genomics has brought a prospect of finding new antibiotics and more and more new action targets will be discovered.

关 键 词：抗生素 抗生素筛选 基因组 靶向抗生素筛选 

分 类 号：R978.1[医药卫生—药品]