毒理学关注阈值(TTC)在化学物质风险评估中的应用  

Use of threshold of toxicological concern for chemical substances safety assessment

作　　者：郑明岚[1] 周少英 刘学军 周志俊[1] 

机构地区：[1]复旦大学公共卫生学院教育部公共卫生安全重点实验室WHO职业卫生合作中心(上海),上海200032 [2]P&G Group,USA

出　　处：《卫生研究》2010年第5期639-642,共4页Journal of Hygiene Research

基　　金：上海市公共卫生重点学科建设项目(No08GWZX0303,08GWD20)

摘　　要：毒理学关注阈值方法是一种毒理学风险评价工具,当人体暴露剂量低于化学品的毒理学关注阈值时,该化学品对人体健康造成负面影响的可能性很低。TTC方法最早用在食品包装材料方面的风险评估,目前TTC方法已应用于食品包装物、食用香料、药物、工业化学品、化妆品等领域的安全性评价。TTC方法为化学物质的安全评价提供了有用的评价工具。The Threshold of Toxicological Concern（TTC） approach is a risk assessment tool of toxicology.When the exposure dose of human body is below the TTC of chemicals,the likelihood of that chemical causing negative influence on the human health is very low.Earliest,TTC approach was used in the risk assessment of in the respect of the food packing materials.Currently,TTC approach is used for safety assessment in the fields of food packing material,flavoring agents,medicine,industry chemicals,cosmetics,and etc.TTC approach provides useful assessment tool for the safety evaluation for the chemical substances.

关 键 词：毒理学关注阈值 化学物质 风险评估 

分 类 号：R994.6[医药卫生—毒理学]