清风胶囊镇静催眠作用的实验研究  

Study on the sedative and hypnotic effects of Qingfeng capsule

作　　者：刘伟 雷晓林 莫志贤[2] 

机构地区：[1]东方药林药业有限公司,广州510510 [2]南方医科大学,广州510510

出　　处：《中国药物滥用防治杂志》2010年第5期262-265,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究清风胶囊的镇静作用。方法:通过小鼠自发活动实验和戊巴比妥钠阈下剂量诱导睡眠及睡眠时间实验,观察清风胶囊的镇静作用。结果:低、中、高三剂量清风胶囊(1.0,2.0,4.0g/kg,ig)能明显减少小鼠的自发活动,抑制由吗啡引起的小鼠兴奋性增加,使戊巴比妥钠阈下睡眠剂量诱导入睡小鼠数增多,并明显延长戊巴比妥钠的睡眠时间。结论:清风胶囊具有一定的镇静催眠作用,并呈现一定的量效关系。Objective：to study the sedative function of Qingfeng Capsule. Methods： observe the abirritative and hypnotic function of Qingfeng Capsule through experiment on rats＇ voluntary movements and trails on repose, as well as the time of repose induced by subdose of Pelltobarbitalum Natricum. Results： three doses （ under-dose 1.0, middle-dose 2.0, upper-dose 4.0） of Qingfeng Capsule could distinctively cut down rats＇ voluntary movements, curb the increased excitation of rats induced by Morphine, increase the number of rats that induced to repose by subdose of Pelltobarbitalum Natricum, and obviously lengthen the time of repose. Conclusion： Qingfeng Capsule has a function of sedation and hypnosis, and shows a relation between dose and efficiency.

关 键 词：清风胶囊 镇静 催眠 小鼠 吗啡 

分 类 号：R285.5[医药卫生—中药学]