D-A环合芳构化法合成4-氯代苯酐  

Synthesis of 4-chlorophthalic anhydride with D-A cyclization and aromatization

作　　者：孙一飞[1] 张华[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室,辽宁大连116012

出　　处：《化工进展》2010年第10期1963-1968,共6页Chemical Industry and Engineering Progress

摘　　要：为了寻找一条高效率合成4-氯代苯酐的路线,基于D-A环合原理和芳构化方法,首先,优化并比较了两条合成4-氯代四氢苯酐(二酸)的路线,然后,优化并比较了两条将4-氯代四氢苯酐(二酸)芳构化合成4-氯代苯酐的路线。得到如下结果:4-氯代四氢苯酐收率提高到95%,纯度大于98%;用液溴作芳香化试剂4-氯代苯酐的单步收率达到89%、纯度99%,氧气活性炭作芳香化试剂,4-氯代苯酐收率达到70%、纯度100%。Synthesis of 4-chlorophthalic anhydride（acid）was investigated based on D-A cyclization and aromatization. Two synthetic routes for 4-chlorotetrahydrophthalic anhydride,and its two aromatizing ways were optimizated and compared. The yield of 4-chlorotetrahydrophthalic anhydride was increased to 95% with purity higher than 98%. The aromatization yield using liquid bromine as the aromatizing reagent was increased to 89% with 99% purity;and the aromatization yield using oxygen and activated carbon as the aromatizing reagent was increased to 70% with 100% purity.

关 键 词：4-氯代苯酐 4-氯代四氢苯酐 马来酸酐 氯丁二烯 D-A环合 芳构化 

分 类 号：TQ203.9[化学工程—有机化工]