周仲瑛教授应用犀角地黄汤临床经验要素数据挖掘分析  

Data mining for clinical experience elements of Professor ZHOU Zhong-ying in applying Rhino Horn and Rehmannia Decoction

作　　者：叶放[1,2] 陶帅[1] 徐吉敏[1] 王方圆[1] 李国春[1] 吴勉华[1] 周学平[1,2] 

机构地区：[1]南京中医药大学国家中医药管理局中医瘀热病机重点研究室,南京210016 [2]国医大师周仲瑛名医工作室,南京210029

出　　处：《中华中医药杂志》2010年第10期1577-1579,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技部973计划中医基础理论专项课题(No.2006CB504807);南京中医药大学基础研究与重点培育专项基金项目(No.09XJC03);南京中医药大学中医内科学重点学科开放课题(No.ZYNK002)~~

摘　　要：目的:提炼周仲瑛教授基于瘀热病机而善用犀角地黄汤治疗难治性疾病的经验要素以推广应用。方法:选择周仲瑛教授以犀角地黄汤为基础方的有效医案317例,对四诊信息进行规范预处理,采用描述性分析、关联规则等方法分析。结果:涉及病种广泛,病位主要在肝、肾;病性多为热、瘀、阴虚、湿、毒。主要四诊信息表征包括舌苔黄占77.60%,舌质红或暗占52.37%-76.97%,腻苔占55.84%;热象占38.83%;疼痛39.74%;出血征占30.04%等。总计涉及269味中药,每例患者每次用19.93味药,与凉血、清热、解毒、化湿、滋阴等5类药物配伍占83.31%。结论:犀角地黄汤适用于多种难治性病证,瘀热相关病机演变每多复杂,临证要把握"瘀热"病机主要信息表征特征,随证加减,灵活施治。Objective：To refine the experience of Professor ZHOU Zhong-ying＇s blood stasis and heat pathogenesis in using Rhino Horn and Rehmannia Decoction to treat refractory disease,and expand the application.Methods：317 cases using Rhino Horn and Rehmannia Decoction were included,analysed the medical information by means of descriptive analysis,association rules methods.Results：A wide range of disease were involved,and location mainly lied in the liver and kidney;pathogenes lied in heat,blood stasis,yin deficiency,wet,and poisons;including the tongue,77.6% yellow,red or dark tongue accounted for 52.37%-76.97%,sticky coating accounting for 55.8%;heat accounted for 38.83%,pain 39.74%,bleeding 30.04%;a total of 269 herbs involved,with 19.93 herbs per patient,the herbs of cooling blood,eliminating heat,detoxification,dispersing dampness,nutritue yin accounted for 83.31%.Conclusion：Rhino Horn and Rehmannia Decoction for a variety of refractory disease,grasping the main features of the pathogenesis of blood stasis and heat was essential for clinical application.

关 键 词：犀角地黄汤 瘀热 经验要素 周仲瑛 

分 类 号：R249.2[医药卫生—中医临床基础] R289[医药卫生—中医学]