新疆维吾尔族原发性胆汁性肝硬化患者的生化和免疫学特征  

Biochemical and immunological index features of patients with primary biliary cirrhosis(PBC)in Uygur people of Xinjiang

作　　者：罗德梅[1] 赵春梅[2] 张琼[1] 罗莉[2] 

机构地区：[1]新疆医科大学第一附属医院医学检验中心,乌鲁木齐830000 [2]新疆医科大学第一附属医院风湿免疫科,乌鲁木齐830000

出　　处：《中国免疫学杂志》2010年第9期842-844,858,共4页Chinese Journal of Immunology

摘　　要：目的:分析维吾尔族与汉族原发性胆汁性肝硬化(PBC)患者的肝功能生化和免疫学特征。方法:对60例维吾尔族与60例汉族PBC患者的肝功能生化及免疫学指标进行分析比较差别。结果:维吾尔族60例PBC患者抗核抗体(ANA)、抗线粒体抗体(AMA)、抗线粒体-2型抗体(AMA-2)阳性率分别为61.7%(37/60)、96.7%(58/60)、95.0%(57/60);汉族60例PBC患者中ANA、AMA、AMA-2抗体阳性率分别为70.0%(42/60)、100.0%(60/60)、96.7%(58/60)。两组PBC患者肝功能异常均以胆汁淤积为主,伴有高水平的IgM血症和自身抗体。结论:维吾尔族PBC患者多发于中年女性,肝生化、免疫学指标异常与汉族PBC患者无差异。PBC发病不受地区和人种的限制。Objective：To analyze biochemical and immunological index features of patients with PBC in Uygur and Han people of Xinjiang.Methods：The difference was compared between 60 patients with PBC in Uygur people and Han people by examination of biochemical and immunological index.Results：The positive rate of ANA,AMA and AMA-M2 was 61.7%（37/60）,96.7%（58/60） and 95.0%（57/60）in 60 cases patients with PBC of the Uygur people;The positive rate of ANA ,AMA and AMA-M2 was 70.0%（42/60）,100.0%（60/60） and 96.7%（58/60） in 60 cases patients with PBC of the Han people;A cholestatic pattern was especially revealed in the abnormal liver functions,with high levels of IgM and autoantibodies accompanied in all the PBC patients.Conclusion：PBC with Uygur and Han people frequently affects middle-aged women,and there is no significant difference in abnormity of the biochemical and immunological indexes between the two groups.Be attacked by PBC is not received the restriction of race and district.

关 键 词：维吾尔族 肝硬化 胆汁性 肝炎 抗线粒体抗体 

分 类 号：R593.2[医药卫生—内科学]