傅里叶变换红外光谱法检测脑肿瘤  

FTIR Spectroscopic Study on Brain Tumors

作　　者：潘庆华[1,2] 万伟庆[3] 贾桂军[3] 徐怡庄[1] 来国桥[2] 刘少轩[1] 陈静[1] 杨丽敏[1] 张元福[1] 翁诗甫[1] 吴瑾光[1] 

机构地区：[1]北京大学化学与分子工程学院,北京100871 [2]杭州师范大学有机硅化学与材料重点实验室,杭州310012 [3]首都医科大学附属北京天坛医院,北京100083

出　　处：《高等学校化学学报》2010年第9期1717-1720,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:30371604,50203001,20171004)资助

摘　　要：应用傅里叶变换红外光谱法检测了28例液氮冻存的离体脑肿瘤样本及其残留物(将脑肿瘤样本从ATR的ZnSe晶片上取下,样本在ZnSe晶片上沾染后留下的物质).结果发现,神经鞘瘤和神经上皮组织肿瘤(如星形细胞瘤等)的主要特征吸收峰存在明显差异,因此可从各个特征吸收峰的峰位、峰形及不同谱峰强度比的变化来初步鉴别脑肿瘤的性质,脑肿瘤组织样品残留物的红外光谱也可反映不同性质脑肿瘤的差异.与脂类糖蛋白以及核酸相关的谱带变化分析表明,通过特征峰强比(I1460cm-1/I1400cm-1,I1160cm-1/I1120cm-1和I1160cm-1/I1080cm-1)来鉴别肿瘤的性质与病理诊断结果的符合率超过85%.In the present investigation,28 patients with brain tumor were recruited for FTIR spectroscopic measurement. These obtained FTIR spectra were analyzed and compared. It was found that there were significant differences in the spectral features of neurinoma and tumours of neuroepithelial tissue（ e. g. astrocytoma） such as the changes in peak position,band shape and relative intensity of the bands including the main indexes I1460 cm-1 /I1400 cm-1,I1160 cm-1 /I1120 cm-1 and I1160 cm-1 /I1080 cm-1 in the ranges of 1000—1800 cm-1. The similar differences in the spectral features of the residue of the brain tumor was found. The results show that the relative intensity of the bands（ such as I1460 cm-1 /I1400 cm-1,I1160 cm-1 /I1120 cm-1 and I1160 cm-1 /I1080 cm-1） can be used to distinguish neurinoma from tumours of neuroepithelial tissue（ such as astrocytoma） which are in agreement with the pathological results larger than 85% .

关 键 词：傅里叶变换中红外光谱 衰减全反射 脑肿瘤 

分 类 号：O657.33[理学—分析化学]