超声波促进离子液体中Biginelli一锅法合成苯并咪唑并[2,1-b]喹啉-6-酮  

One-pot Biginelli Synthesis of Benzimidazo[2,1-b]quinazolin-6-ones in Ionic Liquid Phase Under Ultrasound Irradiation

作　　者：赵新海[1] 刘晨江[1] 李燕萍[1] 

机构地区：[1]新疆大学化学化工学院,理化测试中心,石油天然气精细化工教育部重点实验室,乌鲁木齐830046

出　　处：《高等学校化学学报》2010年第9期1769-1773,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20662009;20862016)资助

摘　　要：在超声波辐射下,芳香醛、1,3-环己二酮和2-氨基苯并咪唑3组分在离子液体([bmim]Br)介质中经Biginelli反应"一锅煮"合成了一系列新型苯并咪唑并[2,1-b]喹啉-6-酮衍生物.2-氨基苯并咪唑的使用是对经典的Biginelli反应的发展,并且该方法具有反应条件温和、产率较高(65%～86%)及环境友好等优点.产物经IR,1HNMR和元素分析确证了结构.A novel series of benzimidazo[2,1-b]quinazolin-6-ones derivatives was synthesized by a threecomponent Biginelli condensation reaction of aldehydes,2-aminobenzimidazole and 1,3-cyclohexanedione, employing ionic liquid[bmim]Br as a solvent under ultrasound irradiation. The classical Bignelli reaction has been extended by the use of 2-aminobenzimidazole and this method has the advantages of milder reaction conditions,short reaction time（ 0. 5 h） ,good yields（ 65% —86% ） and environmental benignity. The structures of the products were characterized by IR,1H NMR spectra and elemental analysis.

关 键 词：Biginelli反应 苯并咪唑并[2 1-b]喹啉-6-酮 超声波辐射 离子液体 

分 类 号：O621.25[理学—有机化学]