瘦素受体基因Gln223 Arg多态性与代谢综合征患者胰岛素抵抗的相关性  

Association of leptin receptor gene GIn223Arg polymorphism with insulin resistance in patients with metabolic syndrome

作　　者：陈海翎[1] 邓丽丽[1] 李菊芬[1] 

机构地区：[1]北京积水潭医院内分泌科,100035

出　　处：《中华内分泌代谢杂志》2010年第9期754-757,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 研究瘦素受体基因Gln223Arg多态性与代谢综合征（MS）患者胰岛素抵抗的相关性.方法 代谢综合征组167例,对照组216名,以聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法分析其瘦素受体基因型,并进行临床生化检测.结果 携带A等位基因者发生MS的风险是G等位基因的3.302倍（P〈0.01）.携带A等位基因的MS患者发生胰岛素抵抗的风险是G等位基因的3.446倍（P〈0.01）.结论 瘦素受体基因Gln223Arg多态性A等位基因携带者发生MS的风险增加,更容易发生胰岛素抵抗.Objective To investigate the association of leptin receptor gene Gln223Arg polymorphism with metabolism syndrome and insulin resistance. Methods The genotypes of leptin receptor in 167 patients with metabolic syndrome and 216 healthy subjects were determined by polymerase chain reaction restriction fragment length polymorphism. The biochemical indicators were detected. Results The frequency of A alleles was significantly higher in patients with metabolic syndrome than in healthy subjects. The risk of metabolic syndrome in inviduals with allele A was 3. 302 folds of that with allele G（ P〈0.01 ）. Compared with allele G, the patients withA allele had higher body mass index,blood pressure, blood glucose, insulin level, waist circumference, and more serious dyslipidemia. The risk of insulin resistance in patients with A allele was 3. 446 folds of that with allele G （P〈0.01）. Conclusions Leptin receptor gene Gln223Arg polymorphism is associated with an increased risk of metabolic syndrome and insulin resistance.

关 键 词：瘦素受体 基因 多态性 单核苷酸 代谢综合征 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]