慢性肺部疾病患者接种23价肺炎链球菌多糖疫苗后抗荚膜多糖抗体的特异性  

Specificity of antibody response to 23-valent pneumococcal polysaccharide vaccine in patients with chronic pulmonary diseases

作　　者：陈蒙[1] 赵德育[1] 

机构地区：[1]南京医科大学附属南京儿童医院呼吸病科,210008

出　　处：《江苏医药》2010年第17期2002-2004,共3页Jiangsu Medical Journal

摘　　要：目的探讨慢性肺部疾病患者接种23价肺炎链球菌多糖疫苗(PPV)后血清中抗肺炎链球菌荚膜多糖(CPS)IgG抗体的特异性。方法以39例慢性肺部疾病患者为研究对象,分别用第二代和特异性更高的第三代ELISA测定疫苗接种前、后血清中的肺炎链球菌6B、19F和23F三种血清型的特异性IgG抗体浓度。结果用第三代ELISA测得的患者血清中血清型特异性IgG抗体水平比用第二代ELISA测得的抗体水平显著降低。无论是PPV接种前的自然感染,还是PPV接种后的主动免疫,慢性肺部疾病患者血中产生的抗CPS-IgG中都有大约一半的非特异性抗体。结论 PPV接种并不能提高慢性肺部疾病患者血中的特异性抗CPS-IgG的比例。Objective To study the specificity of the serotype-specific IgG in the sera of patients with chronic pulmonary diseases（CPD）after pneumococcal vaccination.Methods Serotype-specific IgG concentrations were measured by the second and third（with more specificity）generation ELISA for serotype 6B,19F and 23F in 39 CPD patients after vaccinated with 23-valent pneumococcal polysaccharide vaccine（PPV）.Results The serotype-specific IgG levels measured by the third-generation ELISA were much lower than those by the second-generation ELISA.About half of the anti-CPS IgG in the sera of CPD patients was non-specific antibody whether natural infection or vaccination.Conclusion PPV can not improve the proportion of serotype-specific antibodies in the sera of patients with CPD.

关 键 词：肺炎链球菌多糖疫苗 慢性肺部疾病 血清型特异性IgG 

分 类 号：R563[医药卫生—呼吸系统]