格拉司琼不同给药模式对吗啡镇痛患者恶心呕吐的影响  

Effects of ondansetron administration on postoperative nausea and vomiting in patients undergoing analgesia with morphine

作　　者：司马华杰 姜春南[1] 

机构地区：[1]丹阳市人民医院麻醉科,212300

出　　处：《江苏医药》2010年第17期2038-2039,共2页Jiangsu Medical Journal

摘　　要：目的比较格拉司琼不同给药方式对吗啡术后镇痛引起的术后恶心呕吐(PONV)的防治作用。方法 60例妇产科手术患者均分为三组。Ⅰ组格拉司琼3mg加入镇痛泵中;Ⅱ组格拉司琼3mg在给吗啡负荷量前5min缓慢静脉滴注;Ⅲ组静脉滴注格拉司琼3mg(同Ⅱ组),另外在镇痛泵中加入格拉司琼3mg。记录并比较术后VAS疼痛评分、PONV、和第一次肛门排气时间。结果Ⅰ组PONN发生率高于Ⅱ、Ⅲ组(40%vs.20%and10%)(P<0.05),且大部分发生在术后24h内。排气时间三组分别为(49±12)h、(45±10)h、(47±12)h,组间差异无显著性(P>0.05)。结论临床应用格拉司琼需给予负荷量,从而有效减少PONV的发生。Objective To observe the effects of ondansetron administration on postoperative nausea and vomiting（PONV）in patients undergoing analgesia with morphine.Methods Sixty gynacological patients were divided into three groups with 20 cases each.Postoperative intravenous anagesia（PCIA）with morphine was given in all cases.Ondansetron 3mg was added to analgesic solution in group Ⅰ,which was injected before PCIA in group Ⅱ or injected before PCIA and added in analgesic solution in group Ⅲ.The results of analgesia,PONV and the time of first gas out were recorded.Results The incidence of PONV was higher in group I than that in groups of Ⅱ and Ⅲ（40% vs.20% and 10%）（P0.05）.Conclusion Intravenous injection of ondansetron before PCIA can effectively reduce the incidence of PONV.

关 键 词：格拉司琼 吗啡 镇痛 

分 类 号：R614[医药卫生—麻醉学]