具有回复系统的控释地诺前列酮阴道栓剂用于足月胎膜早破病例引产的临床研究  

Clinical study of the effects of dinoprostone on induction of prerupture pregnancies in term

作　　者：潘晓玉[1] 金妍[1] 徐杨[1] 李春凤[1] 郑郑[1] 

机构地区：[1]北京中日友好医院妇产科,100029

出　　处：《新医学》2010年第9期582-584,共3页Journal of New Medicine

摘　　要：目的:探讨具有回复系统的控释地诺前列酮阴道栓剂(欣普贝生)用于足月胎膜早破病例引产的有效性及安全性。方法:52例足月胎膜早破需要引产孕妇以随机列表法分为观察组(30例)和对照组(22例),分别用欣普贝生和缩宫素引产。比较两组产妇促子宫颈成熟有效率、子宫颈Bishop评分、临产及分娩时间、新生儿情况及药物不良反应。结果:观察组用药24h内有效29例,无效1例,总有效率为97%。对照组24h内有效6例,25～48h有效8例,49～72h有效4例,无效4例,总有效率为82%。观察组均于48h内终止妊娠,其用药24h子宫颈Bishop评分明显高于对照组(P<0.05)。用药后观察组的临产时间及总产程分别为(9.2±5.7)、(26.4±9.5)h,均短于对照组相应的(7.3±5.4)、(11.9±5.0)h(P<0.01或0.05)。观察组阴道分娩20例(67%),对照组阴道分娩14例(64%),两组的阴道分娩率比较差异无统计学意义(P>0.05)。观察组发生胎儿窘迫3例,新生儿窒息1例;对照组发生胎儿窘迫2例,无发生新生儿窒息者。两组胎儿窘迫发生率、新生儿窒息率比较差异均无统计学意义(P>0.05)。观察组发生子宫收缩过频3例,产后出血1例(3%),对照组无上述不良反应发生。结论:欣普贝生用于足月胎膜早破病例引产,促子宫颈成熟有效率高,临产时间快,总产程短,对新生儿不良影响小,但使用时须密切观察孕妇子宫收缩及胎心情况,以防产后出血的发生。Objective：To evaluate the efficacy and safety of controlled releasing dinoprostone pessary （Propess） in induction of premature rupture of the membrane （PROM） pregnancies in term. Methods： Fifty-two cases of PROM pregnancies in term were randomly divided into two groups. Propess and oxytocin were used in 30 and 22 cases, respectively. The cervical ripening rate, induction-delivery interval, time of birth process, Bishop scoring, vaginal delivery and Caesarean section rates, and the side effects of drugs were compared between the two groups. Results： Compared with oxytocin, the cervical ripening rate was higher in Propess group （96.7% vs 81.8%）, with lower induction-delivery interval （9.2±5.7 h vs 26.4±9.5 h）, and shorter birth process （7.3±5.4 h vs 11.9±5.0 h）. There was no significant difference in vaginal delivery and Caesarean section rates. No side effect was observed. Conclusion： Propess can be used for induction of PROM pregnancy in term effectively and safely.

关 键 词：地诺前列酮 缩宫素 胎膜早破 促宫颈成熟 

分 类 号：R719.3[医药卫生—妇产科学]