术前静脉输注不同剂量泮托拉唑钠对患者术中胃液酸度的影响  

Effects of preoperative intravenous different doses of pantoprazole on acidity of gastric fluid

作　　者：杨帆[1] 高林林[1] 苑妍新[2] 孟凌新[1] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳市110004 [2]黑龙江省大庆龙南医院麻醉科

出　　处：《中华麻醉学杂志》2010年第6期664-666,共3页Chinese Journal of Anesthesiology

摘　　要：目的 评价术前静脉输注不同剂量泮托拉唑钠对患者术中胃液酸度的影响.方法 择期外科手术患者60例,随机分为3组（n=20）,生理盐水组（N组）入室后于15 min内静脉输注生理盐水100ml,P1组和P2组分别静脉输注泮托拉唑钠40和80 mg（用生理盐水稀释至100 ml）.给药后15 min进行麻醉诱导.分别于给药前（基础状态）、给药后1 h、2 h和术毕时抽取胃液,测定pH值.记录术后24 h内头晕、恶心、呕吐和腹泻等不良反应的发生情况.记录术后2周内应激性溃疡的发生情况.结果 与N组比较,P1组和P2组胃液pH值升高,P2组胃液pH值≤2.5发生率和应激性溃疡发生率降低（P＜0.05）.各组间不良反应发生率差异无统计学意义（P＞0.05）.结论 术前静脉输注泮托拉唑钠40 mg可提高术中胃液的pH值,有助于降低应激性溃疡的发生和误吸导致肺损伤的危险.Objective To investigate the effects of preoperative iv different doses of pantoprazole on acidity of gastric fluid in patients undergoing elective surgery. Methods Sixty ASA Ⅰ -Ⅲ patients aged 38-80 yr,weighing 44-72 kg undergoing elective surgery were randomly allocated into 3 groups （n = 20 each）： group Ⅰ control （group C）; group Ⅱ pantoprazole 40 mg（group P1） and group Ⅲ pantoprazole 80 mg（group P2）. The patients received intravenous normal saline （NS） 100 ml, pantoprazole 40 and 80 mg in NS 100 ml respectively in group C, P1 and P2 at 30 min before surgery. Gastric content was aspirated using a gastric tube on the patients＇arrival in the operating room and at 1,2 h and the end of surgery. The pH of the gastric fluid was measured. The adverse effects including dizziness, diarrhea, PONV and incidence of stress ulcer were recorded. Results The pH was significantly increased in group P1 and P2 as compared with control group but there was no significant difference in pH between group P1 and P2 . There were no significant difference in the incidence of stress ulcer and pH of the gastric fluid≤2.5 among the 3 groups. Conclusion Preoperative intravenous pantoprazole 40 mg can effectively increase pH of gastric juice and is helpful in reducing the incidence of stress ulcer and the risk of acid aspiration.

关 键 词：苯咪唑类 术前用药法 胃液 氢离子浓度 

分 类 号：R614[医药卫生—麻醉学]