骨代谢的分子调控研究进展  

Research progress on molecular regulation of bone metabolism

作　　者：陈哂媛[1] 巢永烈[1] 

机构地区：[1]四川大学华西口腔医院修复科,四川成都610041

出　　处：《国际口腔医学杂志》2010年第5期544-547,共4页International Journal of Stomatology

摘　　要：骨形成与骨吸收之间的动态平衡受多种因素的调节,骨保护蛋白(OPG)、核因子-κB受体活化因子配体(RANKL)和核因子-κB受体活化因子(RANK)是其关键的调节因子。下面就OPG/RANKL/RANK信号通路、转化生长因子-β、单酰基甘油酰基转移酶-2、骨活化蛋白和交感神经系统在骨代谢调控中的作用作一综述。The dynamic balance between bone formation and bone resorption is regulated by many factors. Osteoprotegerin,receptor activator of nuclear factor-κB and receptor activator of nuclear factor-κB ligand are the key regulatory factors. This article reviewed the regulation mechanism of receptor activator of nuclear factor-κB,receptor activator of nuclear factor-κB ligand,transforming growth factor-β,monoacylglycerol acyltransferase-2,osteoprotegerin,osteoactivin and sympathetic nervous system in bone metabolism.

关 键 词：骨保护蛋白 核因子-ΚB受体活化因子配体 核因子-κB受体活化因子 转化生长因子 

分 类 号：R341[医药卫生—基础医学]