GH-SOCS2-IGF-1轴对溃疡性结肠炎肠黏膜屏障的影响  

Regulatory role of the GH-SOCS2-IGF-1 axis in the pathogenesis of intestinal mucosal barrier dysfunction in ulcerative colitis

作　　者：张榕[1] 施茵[1] 关鑫[1] 

机构地区：[1]上海市针灸经络研究所,上海市200030

出　　处：《世界华人消化杂志》2010年第23期2442-2447,共6页World Chinese Journal of Digestology

基　　金：国家重点基础研究发展计划(973计划)基金资助项目;No.2009CB522900;国家中医药管理局基金资助项目;No.06-07JP17;上海市重点学科基金资助项目;No.S30304~~

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种反复发作的原因不明的肠道慢性非特异性炎症性肠病.由肠黏膜屏障功能异常或损伤而形成的"肠道细菌易位"可介导异常免疫反应和慢性肠道炎症在UC的发生与发展中起着重要作用.近年来研究显示,生长激素(growth hormone,GH)、细胞因子信号抑制蛋白-2(suppressors of cytokine signaling proteins 2,SOCS2)和胰岛素样生长因子-I(insulin like growth factor-1,IGF-1)相互作用形成GH-SOCS2-IGF1轴,参与肠黏膜屏障的损伤与修复过程,而对GH-SOCS2-IGF1轴的调控异常进而导致的肠黏膜屏障功能损伤在UC中的影响作用已日益受到关注.本文旨从GH、SOCS2、IGF-1各自的生物学效应以及GH-SOCS2-IGF-1轴对UC肠黏膜屏障的调节作用等方面作一简要概述.Ulcerative colitis（UC） is a chronic,nonspecific inflammatory bowel disease usually associated with recurrent attacks.Intestinal bacterial translocation induced by intestinal mucosal barrier dysfunction may mediate abnormal immune response and chronic intestinal inflammation and therefore play an important role in the development and progression of UC.The GH-SOCS2IGF1 axis,consisting of growth hormone（GH）,suppressors of cytokine signaling 2（SOCS2）,and insulin-like growth factor-1（IGF-1）,is involved in the injury and repair of intestinal mucosal barrier.The research on the abnormal regulation of the GH-SOCS2-IGF1 axis in the pathogenesis of intestinal mucosal barrier dysfunction in UC has attracted increasing attention.This paper will briefly summarize the respective role of GH,SOCS2,and IGF-1,and discuss the regulatory role of the GH-SOCS2-IGF1 axis in the pathogenesis of intestinal mucosal barrier dysfunction in UC.

关 键 词：GH-SOCS2-IGF-1轴 溃疡性结肠炎 肠黏膜屏障 

分 类 号：R333.3[医药卫生—人体生理学]