姜黄素对溃疡性结肠炎基础及临床疗效的研究进展  

Treatment of ulcerative colitis with curcumin: mechanisms and efficacy

作　　者：陈欧[1] 李昌平[1] 

机构地区：[1]四川省泸州医学院附属医院消化内科,四川省泸州市646000

出　　处：《世界华人消化杂志》2010年第24期2569-2573,共5页World Chinese Journal of Digestology

摘　　要：姜黄素是姜科植物姜黄的提取物,现代药理学研究证实其具有抗炎、抗氧化、抗肿瘤、免疫调节等作用.溃疡性结肠炎是一种病因尚不十分清楚的肠道非特异性炎症性疾病.许多研究表明姜黄素可以通过调节细胞因子释放,抑制核因子κB(nuclear factor-κB,NF-κB)信号通路,激活过氧化物酶增殖剂激活受体(peroxi-some proliferator-activated receptorγ,PPARγ)表达及下调环氧化酶-2(cyclooxygenase-2,COX-2),诱导型一氧化氮合成酶(induciblenitric oxide synthase,iNOS)活性等多种途径阻断多种炎症因子的转录,在实验性的溃疡性结肠炎中发挥抗炎作用.目前有临床研究也证实了姜黄素对溃疡性结肠炎患者具有治疗价值,但临床研究资料相对较少,仍需大量的临床研究来评估姜黄素临床潜力.Curcumin is a natural product isolated from rhizome of Curcuma longa （turmeric）.Extensive research over the past five decades has revealed several important functions of curcumin.Animal studies and clinical trials have suggested that curcumin has antioxidant,antiinflammatory,anti-tumor and immunoregulatory effects.Ulcerative colitis （UC） is a chronic,idiopathic,relapsing intestinal inflammatory disorder of unknown etiology.In experimental colitis,curcumin mediates anti-inflammatory effects by modulating the release of cytokines,inhibiting nuclear factor-κB （NF-κB） and its upstream signaling pathway,activating peroxisome proliferator-activated receptor γ （PPARγ）,and down-regulating the activity of cyclooxygenase-2 （COX-2） and inducible nitric oxide synthase （iNOS）.At present,although there are studies suggesting that curcumin has therapeutic value for patients with UC,further studies are still needed to evaluate the clinical potential of curcumin in these patients.

关 键 词：姜黄素 溃疡性结肠炎 细胞因子 核因子-ΚB 过氧化物体增殖物激活受体-γ 环氧合酶-2 一氧化氮合酶 

分 类 号：R285.5[医药卫生—中药学]