家庭聚集性慢性HBV感染者HBV YMDD自然变异的调查  

Spontaneous HBV YMDD motif mutations in patients with familially clustered chronic HBV infection

作　　者：屈军校[1] 曾庆磊[1] 刘志刚[1] 徐光华[1] 冯继红[1] 赵培东[1] 高晓红[1] 王台[1] 任迎全[1] 

机构地区：[1]延安大学附属医院感染病科,陕西省延安市716000

出　　处：《世界华人消化杂志》2010年第24期2604-2607,共4页World Chinese Journal of Digestology

基　　金：延安市科技计划基金资助项目;No.2007~~

摘　　要：目的:探讨家庭聚集性慢性HBV感染者HBVYMDD自然变异发生情况以及影响其变异的因素.方法:筛选34个共95例有乙型肝炎家庭聚集现象且未经抗病毒治疗的慢性乙型肝炎(chronic hepatitis B,CHB)患者作为家庭组,进行YMDD检测;随机选择82例无乙型肝炎家庭聚集现象且未接受过抗病毒治疗的CHB患者作为对照组,进行YMDD检测.结果:家庭组95例中有51例(53.68%)检测到YMDD自然变异,对照组82例中有21例(25.61%)检测到YMDD自然变异;YMDD自然变异检出率有显著性差异(P<0.05).结论:有乙型肝炎家族聚集史慢性HBV感染者的YMDD自然变异率较没有乙型肝炎家族聚集史慢性HBV感染者的YMDD自然变异率高.AIM： To survey the spontaneous hepatitis B virus （HBV） YMDD mutations in patients with familially clustered chronic HBV infection.METHODS： Ninety-five chronic hepatitis B （CHB） patients,who came from 34 CHB cluster families and did not underwent treatment with any antiviral drugs,and 82 sporadic CHB patients,who did not underwent treatment with any antiviral drugs,were included in this study.YMDD mutations were detected and compared between the two groups of patients.RESULTS： Of the 95 patients with familial clus-tering of chronic HBV infection,spontaneous YMDD variants were detected in 51 patients （53.68%）.Of the 82 sporadic CHB patients,YMDD variants were detected in 21 patients （25.61%）.The detection rate of spontaneous YMDD mutations was significantly higher in CHB patients with familial clustering than in sporadic CHB patients （P 0.05）.CONCLUSION： The detection rate of spontaneous YMDD mutations is higher in CHB patients with familial clustering than in those without familial clustering.

关 键 词：慢性乙型肝炎 家庭聚集性疾病 YMDD自然变异 

分 类 号：R512.62[医药卫生—内科学]