加替沙星和左旋氧氟沙星治疗细菌性感染文献的药物经济学评价  

Pharmacoeconomic evaluation based on meta-analysis on the literature of gatifloxacin and levofloxacin in the treatment of bacterial infections

作　　者：张海波[1] 王长青[1] 严瑾[2] 孟玲[2] 

机构地区：[1]南京医科大学公共卫生学院,江苏南京210029 [2]南京医科大学第一附属医院药剂科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2010年第9期1271-1274,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:比较加替沙星与左旋氧氟沙星对于细菌性感染的临床疗效,如果两种方法的临床疗效差异没有统计学意义,再对两种药物进行药物经济学评价。方法:对符合纳入标准的加替沙星和左旋氧氟沙星治疗急性细菌性感染的文献进行Meta分析(共入选10篇文献),用治疗后细菌清除率、临床有效率、临床痊愈率作为指标,用最小成本法进行药物经济学评价。结果:两种药物对细菌性感染的治疗差异无显著性,最小成本法表明,加替沙星的成本较左旋氧氟沙星高。结论:加替沙星与左旋氧氟沙星治疗细菌性感染疾病的疗效相当,对患者来说左旋氧氟沙星的经济学价值高于加替沙星。Objective：To compare the anti-infection efficacy of gatifloxacin and levofloxacin.If there is no statistical difference between the two treatment,the economic evaluation of the two drugs was compared.Methods：Meta analysis of literature（a total of 10 selected literature）,which was in line with the inclusion criteria of gatifloxacin and levofloxacin in the treatment of acute bacterial infection,was processed with the rate of bacterial clearance after treatment,clinical efficacy,clinical cure rate as an indicator,with the minimum cost method for economic evaluation of drugs.Results：The two drugs on the treatment of bacterial infections was no significant difference.The minimum cost method showed that gatifloxacin had a higher cost than levofloxacin.Conclusion：Gatifloxacin and levofloxacin have same efficacy in the treatment of bacterial infections.But the pharmacoeconomics value of levofloxacin is better than gatifloxacin.

关 键 词：加替沙星 左旋氧氟沙星 细菌性感染 meta分析 药物经济学 

分 类 号：F407.7[经济管理—产业经济]