儿童紫癜性肾炎补体C4基因多态性分析  

Gene polymorphism of complement C4 in children with Henoch-Schonlein nephritis

作　　者：韩媛[1] 黄松明[1] 张爱华[1] 张维真[1] 朱春华[1] 

机构地区：[1]南京医科大学附属南京儿童医院肾脏科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2010年第9期1301-1305,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅科技基金(H200747);南京市医学重点发展项目(ZKX08007);南京医科大学校基金(07NMUM085)

摘　　要：目的:探讨补体C4基因多态性与中国汉族儿童紫癜性肾炎(Henoch-Schonlein nephritis,HSPN)的关系。方法:应用聚和酶链反应技术对74例紫癜性肾炎(HSPN)和114例单纯过敏性紫癜(Henoch-Schonlein purpura,HSP)汉族儿童进行补体C4基因型分析。130例性别、年龄匹配的健康汉族儿童作为对照组。分析紫癜性肾炎(HSPN)临床表现、病理改变、疗效、血补体C4水平与其基因多态性的关系。结果:HSP患儿(包括HSPN)C4AQ0频率高于健康对照组(7.98%,0.77%,P<0.01,OR=11.19,95%CI为1.45～85.76)。HSPN组和单纯HSP组C4AQ0频率无统计学差异(7.89%,8.11%,P>0.95)。HSPN患儿C4AQ0组血清补体C4水平(0.22±0.03g/L)低于无C4AQ0组(0.26±0.05g/L),有显著性差异(P<0.05)。HSPN患儿C4AQ0组与无C4AQ0组临床表现、病理类型及疗效无显著性差异(P>0.05)。结论:补体C4基因多态性与汉族儿童HSP易感性有关,与HSPN易感性及临床表现、病理类型及疗效无关。Objective：To study the relationship of complement C4 gene polymorphism in children with Henoch-Schonlein nepritis.Methods：Total of 74 ethnic Han children with HSPN and 114 only with HSP,were enrolled,and 130 age-,sex-and ethnic-matched healthy children were used as the control group.complement C4 gene polymorphism were determined by PCR.The correlations between complement C4 gene polymorphism and clinical presentation,pathlogical changes,therapy effect were analyzed.Results：The frequencies of C4AQ0 in HSP（including HSPN）were significantly higher than those in the control group（7.98% vs.0.77%,P 〈 0.01,OR=11.19,95%CI：1.45～85.76）.The frequencies of C4AQ0 in HSPN did not differ from those in children without nephritis（7.89% vs.8.11%,P 〉 0.95）.Plasma complement C4 levels in HSPN with C4AQ0（0.22±0.03 g /L）were significantly lower than those without C4AQ0（0.26±0.05 g /L）（P 〈 0.05）.There were no significant difference between C4AQ0 and clinical presentation,pathlogical changes,therapy effect of children with HSPN.Conclusion：Complement C4 gene polymorphism may be associated with the development of HSP and seems unrelated to the susceptibility and clinical presentation,pathlogical changes,therapy effect to HSPN.

关 键 词：儿童 紫癜 过敏性 肾炎 补体 基因多态性 

分 类 号：R725.8[医药卫生—儿科]