均匀设计与逐步回归用于尿囊酸合成与优化  

Homogeneous Design and Stepwise Regression as Used for Systematic Optimzation of Allantion Preparation

作　　者：肖敏[1] 湛其亭[1,2] 黄莺 李志良[1] 

机构地区：[1]湖南大学化学化工系药物研究所 [2]长沙电力学院化学系长沙410007 [3]湖南中医学院药学分院长沙410004

出　　处：《吉首大学学报》1999年第2期20-22,共3页

基　　金：国家自然科学基金资助课题

摘　　要：利用均匀实验设计逐步回归分析对三氯乙醛路线合成尿囊酸的条件进行了优化建模 ,找出了主次影响因素 ,获得了较好的合成产率及工艺条件。Systematic invesigations were madde on synthometrics and its applications.Synthometrics was regarded as “Chemometrics in Synthetic Chemistry”or“Synthetic Chemometrics”.Uniform or homogeneous design (UD or HD) and stepwise regression (SR) were used,in this paper,for response modelling and synthesis optimization for preparation of allantion by the pothway of trichloroaldehyde (TCA).The primary factor was found to be reaction tempreature through experiments.The opfimal conditions for preparation of allantion were examined and the synthetic yield was obtained as well.

关 键 词：均匀设计 逐步回归 尿囊酸 优化建模 合成 

分 类 号：TQ463.53[化学工程—制药化工]